ENSG00000058668


Homo sapiens

Features
Gene ID: ENSG00000058668
  
Biological name :ATP2B4
  
Synonyms : ATP2B4 / ATPase plasma membrane Ca2+ transporting 4 / P23634
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 203626561
Gene end: 203744081
  
Corresponding Affymetrix probe sets: 205410_s_at (Human Genome U133 Plus 2.0 Array)   212135_s_at (Human Genome U133 Plus 2.0 Array)   212136_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340930
Ensembl peptide - ENSP00000356187
Ensembl peptide - ENSP00000433577
Ensembl peptide - ENSP00000391150
Ensembl peptide - ENSP00000349165
Ensembl peptide - ENSP00000350310
NCBI entrez gene - 493     See in Manteia.
OMIM - 108732
RefSeq - NM_001684
RefSeq - NM_001001396
RefSeq Peptide - NP_001001396
RefSeq Peptide - NP_001675
swissprot - A0A024R968
swissprot - P23634
swissprot - H0YDG5
swissprot - H7BY13
swissprot - H7BZS8
Ensembl - ENSG00000058668
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b2ENSDARG00000044902Danio rerio
 ATP2B4ENSGALG00000003601Gallus gallus
 Atp2b4ENSMUSG00000026463Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP2B1 / P20020 / ATPase plasma membrane Ca2+ transporting 1ENSG0000007096177
ATP2B3 / Q16720 / ATPase plasma membrane Ca2+ transporting 3ENSG0000006784276
ATP2B2 / Q01814 / ATPase plasma membrane Ca2+ transporting 2ENSG0000015708775


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR034304  Plasma membrane calcium-transporting ATPase 4
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IDA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030317 flagellated sperm motility ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0051001 negative regulation of nitric-oxide synthase activity IDA
 biological_processGO:0051599 response to hydrostatic pressure IMP
 biological_processGO:0070588 calcium ion transmembrane transport IMP
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade IDA
 biological_processGO:0071872 cellular response to epinephrine stimulus IDA
 biological_processGO:0097553 calcium ion transmembrane import into cytosol IC
 biological_processGO:0098703 calcium ion import across plasma membrane IC
 biological_processGO:0098736 negative regulation of the force of heart contraction IDA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:0140199 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IDA
 biological_processGO:1900082 negative regulation of arginine catabolic process IDA
 biological_processGO:1901660 calcium ion export IEA
 biological_processGO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation NAS
 biological_processGO:1902305 regulation of sodium ion transmembrane transport IC
 biological_processGO:1902806 regulation of cell cycle G1/S phase transition IMP
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IMP
 biological_processGO:1903249 negative regulation of citrulline biosynthetic process IDA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0036126 sperm flagellum ISS
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 cellular_componentGO:0097228 sperm principal piece IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity ISS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030165 PDZ domain binding IBA
 molecular_functionGO:0030346 protein phosphatase 2B binding IDA
 molecular_functionGO:0036487 nitric-oxide synthase inhibitor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IPI
 molecular_functionGO:0097110 scaffold protein binding ISS


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000089250 NOS1 / P29475 / nitric oxide synthase 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr