ENSGALG00000003601


Gallus gallus

Features
Gene ID: ENSGALG00000003601
  
Biological name :ATP2B4
  
Synonyms : ATP2B4 / ATPase plasma membrane Ca2+ transporting 4
  
Possible biological names infered from orthology : P23634 / Plasma membrane calcium-transporting ATPase 4 / Q6Q477
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 5209970
Gene end: 5248800
  
Corresponding Affymetrix probe sets: Gga.10113.1.S1_s_at (Chicken Array)   Gga.1556.1.S1_at (Chicken Array)   Gga.7302.1.S1_at (Chicken Array)   GgaAffx.2243.1.S1_s_at (Chicken Array)   GgaAffx.2243.2.S1_at (Chicken Array)   GgaAffx.2243.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005686
Ensembl peptide - ENSGALP00000056409
Ensembl peptide - ENSGALP00000053119
Ensembl peptide - ENSGALP00000050929
NCBI entrez gene - 419934     See in Manteia.
RefSeq - XM_418055
RefSeq - XM_015298962
RefSeq - XM_015298963
RefSeq - XM_015298964
RefSeq - XM_015298965
RefSeq - XM_004948447
RefSeq - XM_015298961
swissprot - A0A1D5PU07
swissprot - A0A1D5PJX0
swissprot - A0A1D5PDT3
swissprot - E1C784
Ensembl - ENSGALG00000003601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b2ENSDARG00000044902Danio rerio
 ATP2B4ENSG00000058668Homo sapiens
 Atp2b4ENSMUSG00000026463Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP2B1 / ATPase plasma membrane Ca2+ transporting 1 / G5E829* / P20020* / Plasma membrane calcium-transporting ATPase 1 *ENSGALG0000003055072
ATP2B2 / ATPase plasma membrane Ca2+ transporting 2 / Q01814* / Q9R0K7* / Plasma membrane calcium-transporting ATPase 2 *ENSGALG0000003090871


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IBA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0051001 negative regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051599 response to hydrostatic pressure IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 biological_processGO:0098736 negative regulation of the force of heart contraction IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:0140199 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IEA
 biological_processGO:1900082 negative regulation of arginine catabolic process IEA
 biological_processGO:1902806 regulation of cell cycle G1/S phase transition IEA
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:1903249 negative regulation of citrulline biosynthetic process IEA
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IBA
 molecular_functionGO:0030346 protein phosphatase 2B binding IEA
 molecular_functionGO:0036487 nitric-oxide synthase inhibitor activity IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008177 NOS1 / nitric oxide synthase 1 / P29475* / Q9Z0J4* / Nitric oxide synthase, brain *  / reaction / complex






 

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