ENSMUSG00000026463


Mus musculus

Features
Gene ID: ENSMUSG00000026463
  
Biological name :Atp2b4
  
Synonyms : Atp2b4 / Plasma membrane calcium-transporting ATPase 4 / Q6Q477
  
Possible biological names infered from orthology : ATPase plasma membrane Ca2+ transporting 4 / P23634
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 133699457
Gene end: 133801041
  
Corresponding Affymetrix probe sets: 10357833 (MoGene1.0st)   10357856 (MoGene1.0st)   1445701_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133187
Ensembl peptide - ENSMUSP00000119242
Ensembl peptide - ENSMUSP00000126957
Ensembl peptide - ENSMUSP00000047978
Ensembl peptide - ENSMUSP00000107883
Ensembl peptide - ENSMUSP00000116941
NCBI entrez gene - 381290     See in Manteia.
MGI - MGI:88111
RefSeq - XM_011248038
RefSeq - XM_006529723
RefSeq - XM_006529724
RefSeq - XM_006529725
RefSeq - XM_006529726
RefSeq - XM_006529727
RefSeq - XM_006529728
RefSeq - NM_001167949
RefSeq - NM_213616
RefSeq Peptide - NP_001161421
RefSeq Peptide - NP_998781
swissprot - F7AAP4
swissprot - F6V4K0
swissprot - Q6Q477
swissprot - E9Q828
Ensembl - ENSMUSG00000026463
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b2ENSDARG00000044902Danio rerio
 ATP2B4ENSGALG00000003601Gallus gallus
 ATP2B4ENSG00000058668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp2b1 / G5E829 / Plasma membrane calcium-transporting ATPase 1 / P20020* / ATPase plasma membrane Ca2+ transporting 1*ENSMUSG0000001994375
Atp2b2 / Q9R0K7 / Plasma membrane calcium-transporting ATPase 2 / Q01814* / ATPase plasma membrane Ca2+ transporting 2*ENSMUSG0000003030273
Atp2b3 / ATPase, Ca++ transporting, plasma membrane 3 / Q16720* / ATPase plasma membrane Ca2+ transporting 3*ENSMUSG0000003137673


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR034304  Plasma membrane calcium-transporting ATPase 4
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction ISO
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0051001 negative regulation of nitric-oxide synthase activity ISO
 biological_processGO:0051599 response to hydrostatic pressure ISO
 biological_processGO:0070588 calcium ion transmembrane transport ISO
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade ISO
 biological_processGO:0071872 cellular response to epinephrine stimulus ISO
 biological_processGO:0098736 negative regulation of the force of heart contraction ISO
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:0140199 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IEA
 biological_processGO:1900082 negative regulation of arginine catabolic process ISO
 biological_processGO:1901660 calcium ion export IEA
 biological_processGO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation NAS
 biological_processGO:1902305 regulation of sodium ion transmembrane transport IC
 biological_processGO:1902806 regulation of cell cycle G1/S phase transition ISO
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress ISO
 biological_processGO:1903249 negative regulation of citrulline biosynthetic process ISO
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030018 Z disc ISO
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 cellular_componentGO:0097228 sperm principal piece IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity ISO
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IMP
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030165 PDZ domain binding IBA
 molecular_functionGO:0030346 protein phosphatase 2B binding ISO
 molecular_functionGO:0036487 nitric-oxide synthase inhibitor activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding ISO
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
Show

Allelic Composition: Cacna2d2du-3J/Cacna2d2du-3J
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cacna2d2du-3J/Cacna2d2du-3J
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic Background: BKSW.129X1-Atp2b4tm1Ges

Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic Background: BKSW.129X1-Atp2b4tm1Ges

Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna2d2du-3J/Cacna2d2du-3J
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacna2d2du-3J/Cacna2d2du-3J
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029361 Nos1 / Q9Z0J4 / Nitric oxide synthase, brain / P29475* / nitric oxide synthase 1*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr