ENSMUSG00000029361


Mus musculus

Features
Gene ID: ENSMUSG00000029361
  
Biological name :Nos1
  
Synonyms : Nitric oxide synthase, brain / Nos1 / Q9Z0J4
  
Possible biological names infered from orthology : nitric oxide synthase 1 / P29475
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 117781032
Gene end: 117958840
  
Corresponding Affymetrix probe sets: 10524909 (MoGene1.0st)   1422949_at (Mouse Genome 430 2.0 Array)   1429887_at (Mouse Genome 430 2.0 Array)   1438483_at (Mouse Genome 430 2.0 Array)   1458626_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127432
Ensembl peptide - ENSMUSP00000099617
Ensembl peptide - ENSMUSP00000120421
Ensembl peptide - ENSMUSP00000138176
Ensembl peptide - ENSMUSP00000138506
NCBI entrez gene - 18125     See in Manteia.
MGI - MGI:97360
RefSeq - XM_017320707
RefSeq - NM_008712
RefSeq - XM_006530188
RefSeq - XM_006530189
RefSeq - XM_006530190
RefSeq - XM_006530191
RefSeq - XM_006530192
RefSeq - XM_006530187
RefSeq Peptide - NP_032738
swissprot - Q9Z0J4
swissprot - S4R1D5
swissprot - S4R255
swissprot - F8WGF2
Ensembl - ENSMUSG00000029361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos1ENSDARG00000068910Danio rerio
 NOS1ENSGALG00000008177Gallus gallus
 NOS1ENSG00000089250Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*ENSMUSG0000002897848
Nos2 / P29477 / Nitric oxide synthase, inducible / P35228* / nitric oxide synthase 2*ENSMUSG0000002082642
Por / P37040 / P450 (cytochrome) oxidoreductase / P16435* / cytochrome p450 oxidoreductase*ENSMUSG0000000551414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001478  PDZ domain
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily
 IPR036034  PDZ superfamily
 IPR036119  Nitric oxide synthase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002028 regulation of sodium ion transport IMP
 biological_processGO:0006809 nitric oxide biosynthetic process IDA
 biological_processGO:0006941 striated muscle contraction IMP
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0009408 response to heat ISO
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IDA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0033555 multicellular organismal response to stress ISO
 biological_processGO:0035066 positive regulation of histone acetylation IMP
 biological_processGO:0042311 vasodilation ISO
 biological_processGO:0042738 exogenous drug catabolic process IMP
 biological_processGO:0043267 negative regulation of potassium ion transport IMP
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050767 regulation of neurogenesis IDA
 biological_processGO:0051346 negative regulation of hydrolase activity IMP
 biological_processGO:0051612 negative regulation of serotonin uptake IDA
 biological_processGO:0051926 negative regulation of calcium ion transport IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 biological_processGO:0098735 positive regulation of the force of heart contraction IMP
 biological_processGO:0098924 retrograde trans-synaptic signaling by nitric oxide IMP
 biological_processGO:0140196 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum ISO
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IDA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Dmdmdx/Y,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmd+,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Spink5m1Btlr/Spink5m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh/J

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001356 increased aggression towards females "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trpm6tm1.1Rws/Trpm6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh/J

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Hmox2tm1Poss/Hmox2tm1Poss,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: B6.129-Nos1tm1(cre)Mgmj

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh/J

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0003023 decreased coronary flow rate "reduced rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003285 gastric hypertrophy "increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003307 pyloric stenosis "a narrowing of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh/J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003821 decreased left ventricle diastolic pressure "decrease in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Hmox2tm1Poss/Hmox2tm1Poss,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0004545 enlarged esophagus "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm2Plh/Nos1tm2Plh
Genetic Background: Not Specified

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0005572 abnormal breathing frequency "deviation from the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Tg(SOD1)76Dpr/0
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Tg(SOD1)76Dpr/0
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008779 abnormal maternal behavior "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Npc1m1N/Npc1m1N
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0008962 abnormal carbon dioxide production "deviation from the normal rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0009008 delayed estrous cycle "onset of the sexual cycle of females occurring at a later than expected day/age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009357 induced seizures "applied stimulation producing uncontrolled electrical activity in the brain, producing a physical convulsion or minor change in physical behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0009854 delayed gastric emptying "an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npbtm1Ywa/Npb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010106 abnormal circulating pyruvate kinase level "abnormal concentration in the blood of the phosphotransferase in the glycolytic pathway that catalyzes the transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and p; deficiency results in hemolytic anemia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dmdmdx/Y,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmd+,Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0010154 abnormal gastroesophageal sphincter physiology "any functional anomaly of the thick circular layer of gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh/J

 MP:0010781 pyloric sphincter hypertrophy "increase in the bulk size of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach, due to cell enlargement or accumulation of fluids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010782 stomach smooth muscle circular layer hypertrophy "increase in the bulk size of the middle layer of the muscularis due to cell enlargement or accumulation of fluids" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0010783 abnormal stomach wall morphology "the layered structure that makes up the stomach, consisting of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6;129S4-Nos1tm1Plh/J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0011462 increased urine bicarbonate level "an increased amount of bicarbonate in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0011749 perivascular fibrosis "invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011882 enlarged duodenum "increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Colin_McKerlie]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026463 Atp2b4 / Q6Q477 / Plasma membrane calcium-transporting ATPase 4 / P23634* / ATPase plasma membrane Ca2+ transporting 4*  / complex / reaction






 

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