ENSGALG00000008177


Gallus gallus

Features
Gene ID: ENSGALG00000008177
  
Biological name :NOS1
  
Synonyms : nitric oxide synthase 1 / NOS1
  
Possible biological names infered from orthology : Nitric oxide synthase, brain / P29475 / Q9Z0J4
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 11357297
Gene end: 11386044
  
Corresponding Affymetrix probe sets: GgaAffx.5134.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013280
Ensembl peptide - ENSGALP00000057794
NCBI entrez gene - 427721     See in Manteia.
RefSeq - XM_004934480
RefSeq - XM_015294873
RefSeq - XM_015294874
RefSeq - XM_015294875
swissprot - E1C799
swissprot - A0A1D5PXU7
Ensembl - ENSGALG00000008177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos1ENSDARG00000068910Danio rerio
 NOS1ENSG00000089250Homo sapiens
 Nos1ENSMUSG00000029361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOS2 / nitric oxide synthase, inducible / P29477* / P35228* / nitric oxide synthase 2*ENSGALG0000003809644
POR / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSGALG0000000205314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001478  PDZ domain
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR023173  NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IEA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0033555 multicellular organismal response to stress IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042738 exogenous drug catabolic process IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051612 negative regulation of serotonin uptake IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 biological_processGO:0098735 positive regulation of the force of heart contraction IEA
 biological_processGO:0098924 retrograde trans-synaptic signaling by nitric oxide IEA
 biological_processGO:0140196 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IBA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003601 ATP2B4 / ATPase plasma membrane Ca2+ transporting 4 / P23634* / Q6Q477* / Plasma membrane calcium-transporting ATPase 4 *  / reaction / complex






 

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