ENSGALG00000038096


Gallus gallus

Features
Gene ID: ENSGALG00000038096
  
Biological name :NOS2
  
Synonyms : nitric oxide synthase, inducible / NOS2
  
Possible biological names infered from orthology : nitric oxide synthase 2 / P29477 / P35228
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 9218216
Gene end: 9237392
  
Corresponding Affymetrix probe sets: Gga.3327.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053749
Ensembl peptide - ENSGALP00000058328
NCBI entrez gene - 395807     See in Manteia.
RefSeq - NM_204961
RefSeq Peptide - NP_990292
swissprot - A0A1D5PZB7
swissprot - A0A1D5PLN0
Ensembl - ENSGALG00000038096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos2aENSDARG00000026925Danio rerio
 nos2bENSDARG00000031976Danio rerio
 NOS2ENSG00000007171Homo sapiens
 Nos2ENSMUSG00000020826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOS1 / nitric oxide synthase 1 / P29475* / Q9Z0J4* / Nitric oxide synthase, brain *ENSGALG0000000817755
POR / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSGALG0000000205317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR023173  NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006527 arginine catabolic process IEA
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IEA
 biological_processGO:0032310 prostaglandin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051712 positive regulation of killing of cells of other organism IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0072604 interleukin-6 secretion IEA
 biological_processGO:0072606 interleukin-8 secretion IEA
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004517 nitric-oxide synthase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0034617 tetrahydrobiopterin binding IEA
 molecular_functionGO:0034618 arginine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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