ENSMUSG00000020826


Mus musculus

Features
Gene ID: ENSMUSG00000020826
  
Biological name :Nos2
  
Synonyms : Nitric oxide synthase, inducible / Nos2 / P29477
  
Possible biological names infered from orthology : nitric oxide synthase 2 / P35228
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 78920787
Gene end: 78960254
  
Corresponding Affymetrix probe sets: 10379228 (MoGene1.0st)   1420393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018610
Ensembl peptide - ENSMUSP00000150558
NCBI entrez gene - 18126     See in Manteia.
MGI - MGI:97361
RefSeq - XM_006532446
RefSeq - NM_001313921
RefSeq - NM_001313922
RefSeq - NM_010927
RefSeq Peptide - NP_001300850
RefSeq Peptide - NP_001300851
RefSeq Peptide - NP_035057
swissprot - P29477
swissprot - A0A1L1STZ4
Ensembl - ENSMUSG00000020826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos2aENSDARG00000026925Danio rerio
 nos2bENSDARG00000031976Danio rerio
 NOS2ENSGALG00000038096Gallus gallus
 NOS2ENSG00000007171Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nos1 / Q9Z0J4 / Nitric oxide synthase, brain / P29475* / nitric oxide synthase 1*ENSMUSG0000002936152
Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*ENSMUSG0000002897850
Por / P37040 / P450 (cytochrome) oxidoreductase / P16435* / cytochrome p450 oxidoreductase*ENSMUSG0000000551417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily
 IPR036119  Nitric oxide synthase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0006527 arginine catabolic process IDA
 biological_processGO:0006801 superoxide metabolic process IMP
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IDA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0032310 prostaglandin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051712 positive regulation of killing of cells of other organism IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071345 cellular response to cytokine stimulus ISO
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:0072604 interleukin-6 secretion IEA
 biological_processGO:0072606 interleukin-8 secretion IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0034617 tetrahydrobiopterin binding IDA
 molecular_functionGO:0034618 arginine binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000199 abnormal circulating albumin level "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh
Genetic Background: B6.129S4-Nos1tm1Plh

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: B6.129P2-Sftpa1tm1Kor

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: B6.129P2-Sftpa1tm1Kor

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau/J

 MP:0001881 abnormal mammary gland physiology "aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin

Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2+
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0002602 abnormal eosinophil count "deviation from the normal numbers of eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Tg(Myh6-Tnf)1.6Amf/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin

Allelic Composition: ApcMin/Apc+,Nos2tm1Lau/Nos2+
Genetic Background: B6.Cg-Nos2tm1Lau ApcMin

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003823 increased left ventricular developed pressure "increase in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003930 abnormal tooth hard tissue morphology "defects in the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003966 abnormal adrenocorticotropin level 
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0003995 abnormal uterine artery morphology "malformation of the branch of the internal iliac artery that supplies the uterus and the upper part of the vagina" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Tg(Myh6-Tnf)1.6Amf/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0004389 abnormal respiratory bronchiole morphology "any structural anomaly of the smallest bronchioles, which connect the terminal bronchioles to alveolar ducts and have alveoli rising from their walls" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau/J

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau/J

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005124 increased circulating prolactin level "greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005183 abnormal circulating estradiol level "aberration in the blood concentration of this most potent estrogen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Tg(Myh6-Tnf)1.6Amf/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005610 increased circulating antidiuretic hormone level "greater than the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0006141 abnormal atrioventricular node conduction "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Tg(Myh6-Tnf)1.6Amf/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0006308 enlarged seminiferous tubules "increased diameter of the tubules in the testes where spermatogenesis occurs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0008287 abnormal subiculum morphology "any structural anomaly of the transitional zone beteween the parahippocampal gyrus and the Ammon gyrus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Liew/Nos2tm1Liew
Genetic Background: involves: 129P2/Ola * MF1

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008775 abnormal heart ventricular pressure "any anomaly in the pressure within a cardiac ventricle" [MESH:G09.330.553.660.937]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Tg(Myh6-Tnf)1.6Amf/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmd+
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Tg(Myh6-Tnf)1.6Amf/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010781 pyloric sphincter hypertrophy "increase in the bulk size of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach, due to cell enlargement or accumulation of fluids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0010961 increased compact bone mass 
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Nos2tm1Lau

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0011564 decreased urine prostaglandin level "a reduced amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011742 decreased urine nitrite level "lower than normal amount of nitrite (NO2-) in the urine; suggestive of impaired nitric oxide (NO) release" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0011749 perivascular fibrosis "invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013717 hyperlactation "secretion of milk from the mammary gland in excessive amount, or for an abnormally prolonged period" [MGI:Anna]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: B6.129S7-Nos2tm1Mrl

 MP:0020478 abnormal circadian sleep/wake cycle "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau/J

 MP:0020537 decreased subiculum size "decreased size of the subiculum" [MGI:smb]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0030013 improved central nervous system regeneration "faster or more complete regeneration of healthy central nervous system tissue following injury or disease" [] {comment="MGI:anna"}
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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