ENSG00000007171


Homo sapiens

Features
Gene ID: ENSG00000007171
  
Biological name :NOS2
  
Synonyms : nitric oxide synthase 2 / NOS2 / P35228
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q11.2
Gene start: 27756766
Gene end: 27800499
  
Corresponding Affymetrix probe sets: 210037_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000327251
Ensembl peptide - ENSP00000482291
Ensembl peptide - ENSP00000494870
NCBI entrez gene - 4843     See in Manteia.
OMIM - 163730
RefSeq - XM_011524862
RefSeq - NM_000625
RefSeq - XM_011524860
RefSeq - XM_011524861
RefSeq - XM_011524859
RefSeq Peptide - NP_000616
swissprot - P35228
Ensembl - ENSG00000007171
  
Related genetic diseases (OMIM): 145500 - {Hypertension, susceptibility to}, 145500
  611162 - {Malaria, resistance to}, 611162
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos2aENSDARG00000026925Danio rerio
 nos2bENSDARG00000031976Danio rerio
 NOS2ENSGALG00000038096Gallus gallus
 Nos2ENSMUSG00000020826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOS1 / P29475 / nitric oxide synthase 1ENSG0000008925054
NOS3 / P29474 / nitric oxide synthase 3ENSG0000016486750
POR / P16435 / cytochrome p450 oxidoreductaseENSG0000012794818


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily
 IPR036119  Nitric oxide synthase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001912 positive regulation of leukocyte mediated cytotoxicity TAS
 biological_processGO:0002227 innate immune response in mucosa NAS
 biological_processGO:0006527 arginine catabolic process IDA
 biological_processGO:0006801 superoxide metabolic process ISS
 biological_processGO:0006809 nitric oxide biosynthetic process IDA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009617 response to bacterium NAS
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0032310 prostaglandin secretion IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043457 regulation of cellular respiration TAS
 biological_processGO:0045454 cell redox homeostasis TAS
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium NAS
 biological_processGO:0051712 positive regulation of killing of cells of other organism IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0072604 interleukin-6 secretion IDA
 biological_processGO:0072606 interleukin-8 secretion IDA
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005829 cytosol IMP
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0034617 tetrahydrobiopterin binding ISS
 molecular_functionGO:0034618 arginine binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding ISS
 molecular_functionGO:0050661 NADP binding TAS


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Interleukin-4 and Interleukin-13 signaling
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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