4843


Homo sapiens (NCBI)

Features
Gene ID: 4843
  
Biological name :
  
Synonyms : HEP-NOS|INOS|NOS|NOS2A / nitric oxide synthase 2 / NOS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 210037_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 24041029
RefSeq - NC_000017.11
RefSeq - NG_011470.1
RefSeq - NP_000616.3
RefSeq - NM_000625.4
RefSeq - NM_153292.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000007171 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001912 positive regulation of leukocyte mediated cytotoxicity TAS
 biological_processGO:0002227 innate immune response in mucosa NAS
 biological_processGO:0006527 arginine catabolic process IDA
 biological_processGO:0006625 protein targeting to peroxisome TAS
 biological_processGO:0006801 superoxide metabolic process ISS
 biological_processGO:0006809 nitric oxide biosynthetic process IDA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009617 response to bacterium NAS
 biological_processGO:0009725 response to hormone IBA
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0032310 prostaglandin secretion IDA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042742 defense response to bacterium ISS
 biological_processGO:0043457 regulation of cellular respiration TAS
 biological_processGO:0045454 cell redox homeostasis TAS
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium NAS
 biological_processGO:0051712 positive regulation of killing of cells of other organism IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0072604 interleukin-6 secretion IDA
 biological_processGO:0072606 interleukin-8 secretion IDA
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005782 peroxisomal matrix TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0012506 vesicle membrane IBA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IBA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IBA
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0034617 tetrahydrobiopterin binding ISS
 molecular_functionGO:0034618 arginine binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding ISS
 molecular_functionGO:0050661 NADP binding TAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr