ENSMUSG00000028978


Mus musculus

Features
Gene ID: ENSMUSG00000028978
  
Biological name :Nos3
  
Synonyms : Nitric oxide synthase, endothelial / Nos3 / P70313
  
Possible biological names infered from orthology : nitric oxide synthase 3 / P29474
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 24364810
Gene end: 24384474
  
Corresponding Affymetrix probe sets: 10520126 (MoGene1.0st)   1422622_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110742
Ensembl peptide - ENSMUSP00000030834
NCBI entrez gene - 18127     See in Manteia.
MGI - MGI:97362
RefSeq - NM_008713
RefSeq - XM_006535639
RefSeq Peptide - NP_032739
swissprot - E9Q9X4
swissprot - P70313
Ensembl - ENSMUSG00000028978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOS3ENSG00000164867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nos1 / Q9Z0J4 / Nitric oxide synthase, brain / P29475* / nitric oxide synthase 1*ENSMUSG0000002936157
Nos2 / P29477 / Nitric oxide synthase, inducible / P35228* / nitric oxide synthase 2*ENSMUSG0000002082648
Por / P37040 / P450 (cytochrome) oxidoreductase / P16435* / cytochrome p450 oxidoreductase*ENSMUSG0000000551417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily
 IPR036119  Nitric oxide synthase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001542 ovulation from ovarian follicle IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002028 regulation of sodium ion transport IMP
 biological_processGO:0003057 regulation of the force of heart contraction by chemical signal IGI
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IEA
 biological_processGO:0006527 arginine catabolic process IEA
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0014740 negative regulation of muscle hyperplasia IMP
 biological_processGO:0014806 smooth muscle hyperplasia IMP
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IMP
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0050880 regulation of blood vessel size IMP
 biological_processGO:0051346 negative regulation of hydrolase activity IMP
 biological_processGO:0051926 negative regulation of calcium ion transport IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0034617 tetrahydrobiopterin binding IEA
 molecular_functionGO:0034618 arginine binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
NOSTRIN mediated eNOS trafficking
NOSIP mediated eNOS trafficking
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Nos3tm3.1Plh/Nos3tm3.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm1Gdk/Nos3tm1Gdk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3mldy/Casp3mldy
Genetic Background: either: C3H.B6-Casp3mldy or (involves: C3H/HeH * C57BL/6J)

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001378 abnormal ejaculation "anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001379 abnormal penile erection function "altered ability to achieve a rigid and elevated state of the penis when the erectile tissue becomes filled with blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm3.1Plh/Nos3tm3.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mettm1Sst/Mettm1Sst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1Plh/Nos3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.129P2-Nos3tm1Unc

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003023 decreased coronary flow rate "reduced rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Gdk/Nos3tm1Gdk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003033 abnormal pulmonary vascular resistance "deviation from the normal force opposing blood flow in the lung blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003547 abnormal pulmonary pressure "altered tension of the blood within the pulmonary arteries" [J:54986, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003670 dilated glomerular capsule "an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0003821 decreased left ventricle diastolic pressure "decrease in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0004857 abnormal heart weight "anomaly in the average weight of the heart compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004877 abnormal systemic vascular resistance "anomaly in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mbpshi/Mbpshi
Genetic Background: involves: C3H * ICR * SWV

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005186 increased circulating progesterone level "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos3tm3.1Plh/Nos3tm3.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nos3tm1Gdk/Nos3tm1Gdk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nos3tm3.1Plh/Nos3tm3.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.129P2-Nos3tm1Unc

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh Nos1tm1Plh

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: LmnaGt(S7-1F1)Sor/Lmna+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0008823 abnormal ventricular membranous septum morphology "any structural anomaly of the membranous portion of the wall between the two lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008976 delayed female fertility "ability of a female organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009007 short estrous cycle "decrease in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm3.1Plh/Nos3tm3.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009345 abnormal cancellous bone thickness "anomaly in the width of bone that has a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009357 induced seizures "applied stimulation producing uncontrolled electrical activity in the brain, producing a physical convulsion or minor change in physical behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Ptgs1tm1Unc/Ptgs1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: LmnaGt(S7-1F1)Sor/Lmna+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010405 ostium secundum atrial septal defect "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010483 aortic sinus aneurysm "a protruding sac formed by the dilation of the wall of the aortic sinus resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010781 pyloric sphincter hypertrophy "increase in the bulk size of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach, due to cell enlargement or accumulation of fluids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0010814 absent alveolar lamellar bodies "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0010894 pulmonary alveolar edema "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Nos2tm1Lau

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011312 abnormal kidney afferent arteriole morphology "any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011392 increased fetal cardiomyocyte apoptosis "increase in the number of fetal cardiomyocytes undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0011561 renal glomerulus lipidosis "presence of lipid deposits and/or lipid-laden foam cells in the renal glomerular tufts" [MGI:anna]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0011749 perivascular fibrosis "invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0012737 abnormal primary polar body morphology "any structural anomaly of the small cell formed by the first meiotic division of oocytes" [MGI:anna]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000025903 Lypla1 / P97823 / Acyl-protein thioesterase 1 / O75608* / lysophospholipase I*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000028403 Q9D270 / Zdhhc21 / zinc finger, DHHC domain containing 21 / Q8IVQ6* / zinc finger DHHC-type containing 21*  / reaction
 ENSMUSG00000034738 Q6WKZ7 / Nostrin / Q8IVI9* / nitric oxide synthase trafficking*  / complex / reaction
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000007655 Cav1 / P49817 / Caveolin-1 / Q03135*  / complex / reaction
 ENSMUSG00000003421 Nosip / Q9D6T0 / Nitric oxide synthase-interacting protein / Q9Y314*  / complex / reaction
 ENSMUSG00000028978 Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*  / complex
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / reaction






 

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