ENSMUSG00000028403


Mus musculus

Features
Gene ID: ENSMUSG00000028403
  
Biological name :Zdhhc21
  
Synonyms : Q9D270 / Zdhhc21 / zinc finger, DHHC domain containing 21
  
Possible biological names infered from orthology : Q8IVQ6 / zinc finger DHHC-type containing 21
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C3
Gene start: 82798738
Gene end: 82859958
  
Corresponding Affymetrix probe sets: 10514072 (MoGene1.0st)   1429488_at (Mouse Genome 430 2.0 Array)   1435104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120914
Ensembl peptide - ENSMUSP00000030110
Ensembl peptide - ENSMUSP00000102859
Ensembl peptide - ENSMUSP00000121954
Ensembl peptide - ENSMUSP00000133630
NCBI entrez gene - 68268     See in Manteia.
MGI - MGI:1915518
RefSeq - XM_017320373
RefSeq - NM_026647
RefSeq - XM_006538216
RefSeq - XM_011250093
RefSeq - XM_011250094
RefSeq - XM_011250097
RefSeq - XM_017320372
RefSeq Peptide - NP_080923
swissprot - Q5SRN8
swissprot - Q5SRP0
swissprot - Q9D270
swissprot - G3UXC1
Ensembl - ENSMUSG00000028403
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zdhhc21ENSDARG00000110709Danio rerio
 ZDHHC21ENSGALG00000027428Gallus gallus
 Q8IVQ6ENSG00000175893Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R173 / Zdhhc3 / zinc finger, DHHC domain containing 3 / Q9NYG2* / zinc finger DHHC-type containing 3*ENSMUSG0000002578630
Q91WU6 / Zdhhc7 / zinc finger, DHHC domain containing 7 / Q9NXF8* / zinc finger DHHC-type containing 7*ENSMUSG0000003182328
Zdhhc25 / zinc finger, DHHC domain containing 25ENSMUSG0000005411723
Q8BGJ0 / Zdhhc15 / zinc finger, DHHC domain containing 15 / Q96MV8* / zinc finger DHHC-type containing 15*ENSMUSG0000003390622
Q5Y5T3 / Zdhhc23 / zinc finger, DHHC domain containing 23 / Q8IYP9* / zinc finger DHHC-type containing 23*ENSMUSG0000003630422
Q5Y5T1 / Zdhhc20 / zinc finger, DHHC domain containing 20 / Q5W0Z9* / zinc finger DHHC-type containing 20*ENSMUSG0000002196921
P59267 / Zdhhc2 / zinc finger, DHHC domain containing 2 / Q9UIJ5* / zinc finger DHHC-type containing 2*ENSMUSG0000003947021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001594  Palmitoyltransferase, DHHC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0018230 peptidyl-L-cysteine S-palmitoylation ISO
 biological_processGO:0018345 protein palmitoylation ISO
 biological_processGO:0048733 sebaceous gland development IMP
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016409 palmitoyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019706 protein-cysteine S-palmitoyltransferase activity IEA


Pathways (from Reactome)
Pathway description
eNOS activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Ncoa3tm2.2Jxu/Ncoa3tm2.2Jxu
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0002991 abnormal sebaceous gland physiology "anomalous fundtion of any of the small, sacculated organs found within the dermis that normally secrete sebum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0003846 matted coat "coat hairs sticks together to form clumps and does not lie flat" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0008731 abnormal hair shaft melanin granules "any amount or distribution anomaly of pigment polymers in the hair shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0008767 abnormal hair medullary septa cells "septa-forming cells of hair medulla are abnormal in size or arrangement" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0009794 sebaceous gland hyperplasia "overdevelopment and increased size of the sebum secreting glands of the hair shaft, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0010683 dilated hair follicle infundibulum "the luminal space of the hair follicle infundibulum is increased in volume or area, sometimes with an increase of contained fluid or sebum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0011194 abnormal hair follicle physiology "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, MGI:mnk]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

 MP:0013373 increased sebum secretion "increased production and/or release of the lipid-rich substance that is produced by the sebaceous glands, acts to lubricate and waterproof the skin and hair of mammals, and provides antibacterial activity; sebum is released by disintegrating sebocytes that are continuously replaced from progenitors in the periphery of the sebaceous gland; its composition varies across species" [MGI:Anna]
Show

Allelic Composition: Zdhhc21dep/Zdhhc21dep
Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028978 Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr