ENSMUSG00000029684


Mus musculus

Features
Gene ID: ENSMUSG00000029684
  
Biological name :Wasl
  
Synonyms : Q91YD9 / Wasl / Wiskott-Aldrich syndrome-like (human)
  
Possible biological names infered from orthology : O00401 / Wiskott-Aldrich syndrome like
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.1
Gene start: 24613805
Gene end: 24665009
  
Corresponding Affymetrix probe sets: 10543448 (MoGene1.0st)   1426776_at (Mouse Genome 430 2.0 Array)   1426777_a_at (Mouse Genome 430 2.0 Array)   1432155_at (Mouse Genome 430 2.0 Array)   1452193_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031695
Ensembl peptide - ENSMUSP00000043968
NCBI entrez gene - 73178     See in Manteia.
MGI - MGI:1920428
RefSeq - NM_028459
RefSeq - NM_001167745
RefSeq Peptide - NP_001161217
RefSeq Peptide - NP_082735
swissprot - Q3TXX8
swissprot - Q91YD9
swissprot - Q9CXQ9
Ensembl - ENSMUSG00000029684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 waslaENSDARG00000014113Danio rerio
 waslbENSDARG00000006283Danio rerio
 ENSGALG00000037819Gallus gallus
 WASLENSGALG00000008797Gallus gallus
 WASLENSG00000106299Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Was / P70315 / Wiskott-Aldrich syndrome / P42768*ENSMUSG0000003116547


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000697  WH1/EVH1 domain
 IPR003124  WH2 domain
 IPR011026  Wiscott-Aldrich syndrome protein, C-terminal
 IPR011993  PH-like domain superfamily
 IPR030214  Neural Wiskott-Aldrich syndrome protein
 IPR033927  WASP family, EVH1 domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006900 vesicle budding from membrane ISS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0016050 vesicle organization ISS
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030050 vesicle transport along actin filament ISS
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0034629 cellular protein-containing complex localization IMP
 biological_processGO:0045010 actin nucleation TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0051653 spindle localization IMP
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:1903526 negative regulation of membrane tubulation IEA
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis ISS
 biological_processGO:2000402 negative regulation of lymphocyte migration IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030478 actin cap IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
NOSTRIN mediated eNOS trafficking
Nephrin family interactions
EPHB-mediated forward signaling
DCC mediated attractive signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000439 enlarged skull 
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000440 domed skull 
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
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Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000809 absent hippocampus "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000829 dilated fourth ventricle "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000917 obstructive hydrocephaly "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xpctm1Brd/Xpctm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Xpctm1Brd/Xpctm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Wasltm1.1Cgn/Wasltm1.1Cgn
Genetic Background: C57BL/6-Wasltm1.1Cgn

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Xpctm1Brd/Xpctm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xpctm1Brd/Xpctm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Wasltm1.1Ttha/Wasl+,Tg(Nes-cre)1Kag/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002958 aqueductal stenosis "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Wasltm1.1Cgn/Wasltm1.1Cgn
Genetic Background: C57BL/6-Wasltm1.1Cgn

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wasltm1.1Cgn/Wasltm1.1Cgn
Genetic Background: C57BL/6-Wasltm1.1Cgn

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0011057 absent brain ependyma motile cilia "absence of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Wasltm1.1Cgn/Wasltm1.1Cgn
Genetic Background: C57BL/6-Wasltm1.1Cgn

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011202 abnormal ectoplacental cavity morphology "any structural anomaly of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
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Allelic Composition: Wasltm1.1Cgn/Wasltm1.1Cgn
Genetic Background: C57BL/6-Wasltm1.1Cgn

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0011518 abnormal cell chemotaxis "any anomaly in the directed movement of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [GO:0060326]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012003 abnormal septum of telencephalon morphology 
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007655 Cav1 / P49817 / Caveolin-1 / Q03135*  / reaction / complex
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / complex / reaction
 ENSMUSG00000006699 Cdc42 / P60766 / Cell division control   / reaction / complex
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000041734 Q80W68 / Kirrel / Kin of IRRE-like protein 1 / Q96J84* / KIRREL1* / kirre like nephrin family adhesion molecule 1*  / reaction / complex
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / reaction / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex
 ENSMUSG00000034738 Q6WKZ7 / Nostrin / Q8IVI9* / nitric oxide synthase trafficking*  / complex / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex
 ENSMUSG00000006649 Nphs1 / Q9QZS7 / Nephrin / O60500* / NPHS1, nephrin*  / complex / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000028978 Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*  / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000022263 Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex






 

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