ENSMUSG00000034738


Mus musculus

Features
Gene ID: ENSMUSG00000034738
  
Biological name :Nostrin
  
Synonyms : Nostrin / Q6WKZ7
  
Possible biological names infered from orthology : nitric oxide synthase trafficking / Q8IVI9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 69135800
Gene end: 69189330
  
Corresponding Affymetrix probe sets: 10472514 (MoGene1.0st)   1441075_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036923
NCBI entrez gene - 329416     See in Manteia.
MGI - MGI:3606242
RefSeq - NM_181547
RefSeq Peptide - NP_853525
swissprot - Q6WKZ7
Ensembl - ENSMUSG00000034738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nostrinENSDARG00000077866Danio rerio
 Q8IVI9ENSG00000163072Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028535  Nostrin
 IPR031160  F-BAR domain
 IPR035656  Nostrin, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NOSTRIN mediated eNOS trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

Allelic Composition: Nostrintm1Oess/Nostrintm1Oess,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

Allelic Composition: Nostrintm1Oess/Nostrintm1Oess,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007655 Cav1 / P49817 / Caveolin-1 / Q03135*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex / reaction
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000028978 Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*  / reaction / complex
 ENSMUSG00000034738 Q6WKZ7 / Nostrin / Q8IVI9* / nitric oxide synthase trafficking*  / complex






 

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