ENSMUSG00000022607


Mus musculus

Features
Gene ID: ENSMUSG00000022607
  
Biological name :Ptk2
  
Synonyms : P34152 / Ptk2 / PTK2 protein tyrosine kinase 2
  
Possible biological names infered from orthology : protein tyrosine kinase 2 / Q05397
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 73205102
Gene end: 73423280
  
Corresponding Affymetrix probe sets: 10429341 (MoGene1.0st)   1423059_at (Mouse Genome 430 2.0 Array)   1430827_a_at (Mouse Genome 430 2.0 Array)   1440082_at (Mouse Genome 430 2.0 Array)   1443384_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105663
Ensembl peptide - ENSMUSP00000126764
Ensembl peptide - ENSMUSP00000153821
Ensembl peptide - ENSMUSP00000153989
Ensembl peptide - ENSMUSP00000154733
Ensembl peptide - ENSMUSP00000155470
Ensembl peptide - ENSMUSP00000154075
Ensembl peptide - ENSMUSP00000154242
Ensembl peptide - ENSMUSP00000154445
Ensembl peptide - ENSMUSP00000154578
NCBI entrez gene - 14083     See in Manteia.
MGI - MGI:95481
RefSeq - XM_017316429
RefSeq - NM_001130409
RefSeq - NM_001358045
RefSeq - NM_001358046
RefSeq - NM_007982
RefSeq - XM_006520434
RefSeq - XM_006520435
RefSeq - XM_011245452
RefSeq - XM_011245453
RefSeq - XM_017316428
RefSeq - XM_006520415
RefSeq - XM_006520416
RefSeq - XM_006520418
RefSeq - XM_006520420
RefSeq - XM_006520421
RefSeq - XM_006520422
RefSeq - XM_006520423
RefSeq - XM_006520424
RefSeq - XM_006520425
RefSeq - XM_006520426
RefSeq - XM_006520427
RefSeq - XM_006520428
RefSeq - XM_006520429
RefSeq - XM_006520430
RefSeq - XM_006520431
RefSeq - XM_006520432
RefSeq - XM_006520433
RefSeq Peptide - NP_001344974
RefSeq Peptide - NP_001344975
RefSeq Peptide - NP_032008
RefSeq Peptide - NP_001123881
swissprot - P34152
Ensembl - ENSMUSG00000022607
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk2aaENSDARG00000100456Danio rerio
 ptk2abENSDARG00000004672Danio rerio
 PTK2ENSGALG00000031741Gallus gallus
 PTK2ENSG00000169398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945644
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231219
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220919
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012218
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279117
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816615
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611713
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145713
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR005189  Focal adhesion kinase, targeting (FAT) domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036137  Focal adhesion kinase, targeting (FAT) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IDA
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001932 regulation of protein phosphorylation ISO
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007097 nuclear migration IDA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007172 signal complex assembly IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IDA
 biological_processGO:0010632 regulation of epithelial cell migration ISO
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion ISO
 biological_processGO:0030155 regulation of cell adhesion IBA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin ISO
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:0042127 regulation of cell proliferation ISO
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045667 regulation of osteoblast differentiation ISS
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046621 negative regulation of organ growth IGI
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0050771 negative regulation of axonogenesis IMP
 biological_processGO:0051893 regulation of focal adhesion assembly ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0051964 negative regulation of synapse assembly IMP
 biological_processGO:0060396 growth hormone receptor signaling pathway ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:1900024 regulation of substrate adhesion-dependent cell spreading ISO
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IMP
 biological_processGO:2000811 negative regulation of anoikis ISO
 cellular_componentGO:0001725 stress fiber ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008432 JUN kinase binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042169 SH2 domain binding ISO


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Ptk2tm1Imeg/Ptk2tm1Imeg
Genetic Background: CBA.Cg-Ptk2tm1Imeg

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fyntm1Yik/Fyn+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: (WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Mecp2tm1Jchr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ifit2tm1.1Tac/Ifit2+
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1Imeg/Ptk2tm1Imeg
Genetic Background: CBA.Cg-Ptk2tm1Imeg

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptk2tm2.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1Imeg/Ptk2+
Genetic Background: CBA.Cg-Ptk2tm1Imeg

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Ptk2tm1Imeg/Ptk2tm1Imeg
Genetic Background: CBA.Cg-Ptk2tm1Imeg

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Mecp2tm1Jchr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1Imeg/Ptk2tm1Imeg
Genetic Background: CBA.Cg-Ptk2tm1Imeg

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fyntm1Yik/Fyn+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifit2tm1.1Tac/Ifit2+
Genetic Background: involves: C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/?
Genetic Background: involves: C57BL/6J

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002763 ectopic Bergmann glia cells "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:4978]
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Allelic Composition: PhexHyp/?
Genetic Background: involves: C57BL/6J

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptk2tm2.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ptk2tm3.1Guan/Ptk2tm3.1Guan,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ifit2tm1.1Tac/Ifit2+
Genetic Background: involves: C57BL/6

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1Imeg/Ptk2tm1Imeg
Genetic Background: CBA.Cg-Ptk2tm1Imeg

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/?
Genetic Background: involves: C57BL/6J

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1Imeg/Ptk2+
Genetic Background: CBA.Cg-Ptk2tm1Imeg

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm2.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fyntm1Yik/Fyn+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm2.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb7btm2Litt/Zbtb7btm1.2Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: PhexHyp/?
Genetic Background: involves: C57BL/6J

 MP:0010547 abnormal mesocardium morphology "any structural anomaly of the layer of splanchnic mesoderm supporting the embryonic heart in the pericardial cavity; mesocardium normally regresses before birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010656 thick myocardium "increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010664 abnormal vitelline artery morphology "any structural anomaly of the paired arteries that carry blood to the yolk sac from the dorsal aorta; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)105Ayn/0
Genetic Background: FVB.Cg-Trp53tm1Brn Rb1tm2Brn Tg(MMTV-cre)105Ayn

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Ptk2tm1Imeg/Ptk2tm1Imeg
Genetic Background: CBA.Cg-Ptk2tm1Imeg

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Ptk2tm2.1Guan/Ptk2tm2.1Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptk2tm2.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011201 abnormal visceral yolk sac cavity morphology "any structural anomaly of the closed space containing the yolk, formed by the fusion of the edges of the embryonic epiblast (hypoblast) and later surrounded by the visceral yolk sac (hypoblast and visceral yolk sac mesoderm)" [ISBN:0-12-402035-6, PMID:21123814]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.2Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011706 abnormal fibroblast migration "any anomaly of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [GO:0010761]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Ptk2tm1Heen/Ptk2tm1Heen
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012104 small amniotic cavity "reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0012131 small visceral yolk sac "reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013192 decreased sebaceous gland number "fewer than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [MGI:anna]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

 MP:0013585 thymus cortex atrophy "acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Fyntm1Yik/Fyn+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex
 ENSMUSG00000020580 Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000025076 Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / reaction
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / complex / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000022263 Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / reaction / complex
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000027303 Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*  / complex
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex / reaction
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / reaction / complex
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex






 

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