Manteia

ENSDARG00000004672

Danio rerio

Features

Gene ID:	ENSDARG00000004672

Biological name :	ptk2ab

Synonyms :	protein tyrosine kinase 2ab / ptk2ab

Possible biological names infered from orthology :	P34152 / protein tyrosine kinase 2 / PTK2 / PTK2 protein tyrosine kinase 2 / Q05397

Species:	Danio rerio

Chr. number:	16
Strand:	-1
Band:
Gene start:	30735426
Gene end:	30870170

Corresponding Affymetrix probe sets:	Dr.692.1.S1_at (Zebrafish Array) NM_131796_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000155999 Ensembl peptide - ENSDARP00000156652 Ensembl peptide - ENSDARP00000042715 Ensembl peptide - ENSDARP00000109075 Ensembl peptide - ENSDARP00000110764 Ensembl peptide - ENSDARP00000148132 Ensembl peptide - ENSDARP00000149861 Ensembl peptide - ENSDARP00000150323 Ensembl peptide - ENSDARP00000150959 NCBI entrez gene - 142986 See in Manteia. RefSeq - NM_131796 RefSeq Peptide - NP_571871 swissprot - E7F1F9 swissprot - F1QT14 swissprot - F1REU4 ZFIN ID - ZDB-GENE-020114-1 Ensembl - ENSDARG00000004672

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PTK2	ENSGALG00000031741	Gallus gallus
PTK2	ENSG00000169398	Homo sapiens
Ptk2	ENSMUSG00000022607	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000100456	61
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000039577	42
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000022841	42
erbb4a / erb-b2 receptor tyrosine kinase 4a	ENSDARG00000063207	19
si:ch73-383l1.1	ENSDARG00000090408	19
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000036993	18
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *	ENSDARG00000026294	18
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000006202	16
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000104409	15
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000090646	15
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*	ENSDARG00000008186	14
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *	ENSDARG00000069433	13
erbb4b / erb-b2 receptor tyrosine kinase 4b	ENSDARG00000089536	12
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*	ENSDARG00000015752	12
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...	ENSDARG00000013847	5
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*	ENSDARG00000056909	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR000299	FERM domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR005189	Focal adhesion kinase, targeting (FAT) domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR011993	PH-like domain superfamily
IPR014352	FERM/acyl-CoA-binding protein superfamily
IPR017441	Protein kinase, ATP binding site
IPR019748	FERM central domain
IPR019749	Band 4.1 domain
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR029071	Ubiquitin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IBA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007010	cytoskeleton organization	IBA
biological_process	GO:0007155	cell adhesion	IBA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007172	signal complex assembly	IEA
biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0030155	regulation of cell adhesion	IBA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0043066	negative regulation of apoptotic process	IBA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0070309	lens fiber cell morphogenesis	IMP
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005925	focal adhesion	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	IEA
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0005524	ATP binding	IEA

Pathways (from Reactome)

Pathway description

Apoptotic cleavage of cellular proteins

Regulation of actin dynamics for phagocytic cup formation

Integrin alphaIIb beta3 signaling

GRB2:SOS provides linkage to MAPK signaling for Integrins

p130Cas linkage to MAPK signaling for integrins

NCAM signaling for neurite out-growth

EPHB-mediated forward signaling

DCC mediated attractive signaling

VEGFA-VEGFR2 Pathway

RHO GTPases Activate WASPs and WAVEs

RAF/MAP kinase cascade

MET activates PTK2 signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000035	lens	lens nucleus increased amount , abnormal lens cell separated from lens epithelium , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr