Manteia

ENSDARG00000015752

Danio rerio

Features

Gene ID:	ENSDARG00000015752

Biological name :	zap70

Synonyms :	zap70 / zeta chain of T cell receptor associated protein kinase 70

Possible biological names infered from orthology :	P43403 / P43404 / zeta-chain (TCR) associated protein kinase

Species:	Danio rerio

Chr. number:	8
Strand:	1
Band:
Gene start:	20393250
Gene end:	20414364

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000114598 Ensembl peptide - ENSDARP00000006727 NCBI entrez gene - 553615 See in Manteia. RefSeq - NM_001020589 RefSeq Peptide - NP_001018425 swissprot - M9MMB1 swissprot - M9MM92 ZFIN ID - ZDB-GENE-050522-257 Ensembl - ENSDARG00000015752

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ZAP70	ENSGALG00000001486	Gallus gallus
ZAP70	ENSG00000115085	Homo sapiens
Zap70	ENSMUSG00000026117	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*	ENSDARG00000008186	53
si:ch73-383l1.1	ENSDARG00000090408	24
erbb4a / erb-b2 receptor tyrosine kinase 4a	ENSDARG00000063207	24
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *	ENSDARG00000026294	24
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000036993	23
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000004672	22
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000022841	21
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000090646	21
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000104409	20
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000039577	20
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000006202	20
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *	ENSDARG00000069433	19
erbb4b / erb-b2 receptor tyrosine kinase 4b	ENSDARG00000089536	18
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000100456	18
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*	ENSDARG00000056909	8
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...	ENSDARG00000013847	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR000980	SH2 domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR011009	Protein kinase-like domain superfamily
IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR023420	Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001946	lymphangiogenesis	IMP
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0030154	cell differentiation	IBA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	IEA
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0001073	axial vasculature	axial vasculature blood vessel endothelial cell decreased amount , abnormal	Show
ZFA:0001285	intersegmental vessel	intersegmental vessel morphology , abnormal intersegmental vessel aplastic , abnormal	Show
ZFA:0005025	dorsal longitudinal anastomotic vessel	dorsal longitudinal anastomotic vessel morphology , abnormal	Show
ZFA:0005110	thoracic duct	thoracic duct aplastic , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000006468	grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*	/ reaction
ENSDARG00000038059	grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*	/ reaction
ENSDARG00000101169	grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*	/ reaction
ENSDARG00000075962	vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*	/ reaction
ENSDARG00000068763	plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *	/ reaction
ENSDARG00000075437	shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *	/ reaction
ENSDARG00000044718	vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*	/ reaction
ENSDARG00000038442	plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *	/ reaction
ENSDARG00000004433	btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *	/ reaction
ENSDARG00000105276	grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr