ENSDARG00000068763


Danio rerio

Features
Gene ID: ENSDARG00000068763
  
Biological name :plcg2
  
Synonyms : phospholipase C, gamma 2 / plcg2
  
Possible biological names infered from orthology : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885 / Q8CIH5
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 13235714
Gene end: 13293642
  
Corresponding Affymetrix probe sets: Dr.11512.1.A1_at (Zebrafish Array)   Dr.23037.1.A1_at (Zebrafish Array)   NM_001044968_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000075155
Ensembl peptide - ENSDARP00000117776
Ensembl peptide - ENSDARP00000152218
NCBI entrez gene - 561678     See in Manteia.
NCBI entrez gene - 561747     See in Manteia.
RefSeq - NM_001044968
RefSeq Peptide - NP_001038433
swissprot - Q1LWV8
swissprot - Q1LWV9
ZFIN ID - ZDB-GENE-030131-9532
Ensembl - ENSDARG00000068763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCG2ENSGALG00000033507Gallus gallus
 PLCG2ENSG00000197943Homo sapiens
 Plcg2ENSMUSG00000034330Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *ENSDARG0000003844237
si:ch211-260p9.3ENSDARG0000009286225
plce1 / phospholipase C, epsilon 1 / Q8K4S1* / Q9P212* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 *ENSDARG0000008792122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR000980  SH2 domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001452  SH3 domain
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR006571  TLDc domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR016279  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028381  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
 IPR035023  PLC-gamma, C-terminal SH2 domain
 IPR035024  PLC-gamma, N-terminal SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of IP3 and IP4 in the cytosol
Role of phospholipids in phagocytosis
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017565 itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000015752 zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*  / reaction
 ENSDARG00000006468 grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSDARG00000004433 btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *  / reaction / complex
 ENSDARG00000101169 grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction / complex
 ENSDARG00000098477 tec / tec protein tyrosine kinase / P42680*  / complex
 ENSDARG00000102525 lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction






 

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