ENSDARG00000006468


Danio rerio

Features
Gene ID: ENSDARG00000006468
  
Biological name :grap2a
  
Synonyms : grap2a / GRB2-related adaptor protein 2a
  
Possible biological names infered from orthology : GRAP2 / GRB2-related adaptor protein 2 / O75791 / O89100
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 29445473
Gene end: 29468859
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000118723
Ensembl peptide - ENSDARP00000012720
NCBI entrez gene - 550452     See in Manteia.
RefSeq - NM_001017756
RefSeq Peptide - NP_001017756
swissprot - E9QI30
swissprot - Q567F1
ZFIN ID - ZDB-GENE-050417-275
Ensembl - ENSDARG00000006468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000012056Gallus gallus
 GRAP2ENSG00000100351Homo sapiens
 Grap2ENSMUSG00000042351Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*ENSDARG0000010116951
grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000003805939
grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*ENSDARG0000010527639
grapb / GRB2-related adaptor protein b / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000002266837
grapa / GRB2-related adaptor protein a / GRAP* / GRAPL* / Q9CX99* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2-related adapter protein * / GRB2 related adaptor protein like*ENSDARG0000000541436
nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000001820620
nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007536920
nck1a / NCK adaptor protein 1a / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *ENSDARG0000007426220
nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *ENSDARG0000004336119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR017304  Cytoplasmic protein NCK
 IPR035646  GRAP2, C-terminal SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017565 itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex / reaction
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / reaction
 ENSDARG00000015752 zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*  / reaction
 ENSDARG00000004433 btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *  / reaction / complex
 ENSDARG00000101169 grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000006468 grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000098477 tec / tec protein tyrosine kinase / P42680*  / complex
 ENSDARG00000068763 plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000102525 lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction






 

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