ENSG00000100351


Homo sapiens

Features
Gene ID: ENSG00000100351
  
Biological name :GRAP2
  
Synonyms : GRAP2 / GRB2-related adaptor protein 2 / O75791
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 39901082
Gene end: 39973721
  
Corresponding Affymetrix probe sets: 208406_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396355
Ensembl peptide - ENSP00000339186
Ensembl peptide - ENSP00000385607
NCBI entrez gene - 9402     See in Manteia.
OMIM - 604518
RefSeq - XM_006724376
RefSeq - NM_001291824
RefSeq - NM_001291825
RefSeq - NM_001291826
RefSeq - NM_004810
RefSeq Peptide - NP_001278753
RefSeq Peptide - NP_001278754
RefSeq Peptide - NP_001278755
RefSeq Peptide - NP_004801
swissprot - O75791
swissprot - Q6FI14
swissprot - B1AH86
Ensembl - ENSG00000100351
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grap2aENSDARG00000006468Danio rerio
 grap2bENSDARG00000101169Danio rerio
 ENSGALG00000012056Gallus gallus
 Grap2ENSMUSG00000042351Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB2 / P62993 / growth factor receptor bound protein 2ENSG0000017788533
GRAP / Q13588 / GRB2-related adaptor proteinENSG0000015401631
NCK1 / P16333 / NCK adaptor protein 1ENSG0000015809217
NCK2 / O43639 / NCK adaptor protein 2ENSG0000007105116
GRAPL / Q8TC17 / GRB2 related adaptor protein likeENSG0000018915215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035646  GRAP2, C-terminal SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
CD28 co-stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction / complex
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000178562 CD28 / P10747 / CD28 molecule  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000114013 CD86 / P42081 / CD86 molecule  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000121594 CD80 / P33681 / CD80 molecule  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / complex / reaction
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / reaction / complex
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr