ENSG00000114013


Homo sapiens

Features
Gene ID: ENSG00000114013
  
Biological name :CD86
  
Synonyms : CD86 / CD86 molecule / P42081
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q13.33
Gene start: 122055366
Gene end: 122121139
  
Corresponding Affymetrix probe sets: 205685_at (Human Genome U133 Plus 2.0 Array)   205686_s_at (Human Genome U133 Plus 2.0 Array)   210895_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419116
Ensembl peptide - ENSP00000418988
Ensembl peptide - ENSP00000420230
Ensembl peptide - ENSP00000264468
Ensembl peptide - ENSP00000332049
Ensembl peptide - ENSP00000377248
Ensembl peptide - ENSP00000417195
NCBI entrez gene - 942     See in Manteia.
OMIM - 601020
RefSeq - NM_001206924
RefSeq - NM_001206925
RefSeq - NM_006889
RefSeq - NM_175862
RefSeq - NM_176892
RefSeq Peptide - NP_795711
RefSeq Peptide - NP_001193854
RefSeq Peptide - NP_008820
RefSeq Peptide - NP_787058
RefSeq Peptide - NP_001193853
swissprot - P42081
swissprot - H7C4F8
swissprot - C9JXS1
Ensembl - ENSG00000114013
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD86ENSGALG00000014362Gallus gallus
 Cd86ENSMUSG00000022901Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD80 / P33681 / CD80 moleculeENSG0000012159420


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0043017 positive regulation of lymphotoxin A biosynthetic process NAS
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process NAS
 biological_processGO:0045404 positive regulation of interleukin-4 biosynthetic process NAS
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity NAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000163599 CTLA4 / P16410 / cytotoxic T-lymphocyte associated protein 4  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000178562 CD28 / P10747 / CD28 molecule  / reaction / complex
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr