ENSMUSG00000022901


Mus musculus

Features
Gene ID: ENSMUSG00000022901
  
Biological name :Cd86
  
Synonyms : Cd86 / P42082 / T-lymphocyte activation antigen CD86
  
Possible biological names infered from orthology : CD86 molecule / P42081
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 36603869
Gene end: 36666081
  
Corresponding Affymetrix probe sets: 10439312 (MoGene1.0st)   1420404_at (Mouse Genome 430 2.0 Array)   1449858_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087047
Ensembl peptide - ENSMUSP00000117756
NCBI entrez gene - 12524     See in Manteia.
MGI - MGI:101773
RefSeq - XM_011245812
RefSeq - NM_019388
RefSeq - XM_006521741
RefSeq Peptide - NP_062261
swissprot - P42082
swissprot - Q549Q9
swissprot - D3Z363
Ensembl - ENSMUSG00000022901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD86ENSGALG00000014362Gallus gallus
 CD86ENSG00000114013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*ENSMUSG0000007512221


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IGI
 biological_processGO:0042113 B cell activation IDA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome ISO


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic Background: involves: 129S4/SvJae * FVB/N * NOD

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * NOD

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic Background: involves: 129S4/SvJae * FVB/N * NOD

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic Background: involves: 129S4/SvJae * FVB/N * NOD

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

Allelic Composition: Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd86tm1Shr

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
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Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

Allelic Composition: Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd86tm1Shr

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009023 abnormal spinal cord meninges morphology "any structural anomaly in any of the membranes covering the spinal cord, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000026011 Ctla4 / cytotoxic T-lymphocyte associated protein 4 / P16410*  / complex / reaction
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction






 

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