ENSMUSG00000026012


Mus musculus

Features
Gene ID: ENSMUSG00000026012
  
Biological name :Cd28
  
Synonyms : Cd28 / P31041 / T-cell-specific surface glycoprotein CD28
  
Possible biological names infered from orthology : CD28 molecule / P10747
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 60716800
Gene end: 60773359
  
Corresponding Affymetrix probe sets: 10346783 (MoGene1.0st)   1417597_at (Mouse Genome 430 2.0 Array)   1437025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027165
NCBI entrez gene - 12487     See in Manteia.
MGI - MGI:88327
RefSeq - NM_007642
RefSeq Peptide - NP_031668
swissprot - P31041
Ensembl - ENSMUSG00000026012
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD28ENSGALG00000008669Gallus gallus
 CD28ENSG00000178562Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctla4 / cytotoxic T-lymphocyte associated protein 4 / P16410*ENSMUSG0000002601129


Protein motifs (from Interpro)
Interpro ID Name
 IPR008093  T cell antigen CD28
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002863 positive regulation of inflammatory response to antigenic stimulus IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0031295 T cell costimulation IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0045066 regulatory T cell differentiation IEA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IGI
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098636 protein complex involved in cell adhesion ISO
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cc2d1btm1a(KOMP)Wtsi/Cc2d1b+
Genetic Background: Not Specified

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(Cd4-cre)1Cwi/?,Traf6tm2Ywc/Traf6tm2Ywc
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(Cd4-cre)1Cwi/?,Traf6tm2Ywc/Traf6tm2Ywc
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6JSfdAnu

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Cd28tm1Jmg/Cd28tm1Jmg
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd28tm1Jmg/Cd28tm1Jmg
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003278 esophageal inflammation "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: B6.129S2-Cd28tm1Mak/J

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: NOD.129S2-Cd28tm1Mak

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd40lgtm1Flv/Cd40lgtm1Flv
Genetic Background: NOD.Cg-Cd40lgtm1Flv Cd28tm1Mak

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd40lgtm1Flv/Cd40lgtm1Flv
Genetic Background: NOD.Cg-Cd40lgtm1Flv Cd28tm1Mak

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vsx2or-J/Vsx2or-J,Modor3CASA/Rk/?
Genetic Background: involves: 129S1/Sv * CASA/Rk

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cc2d1btm1a(KOMP)Wtsi/Cc2d1b+
Genetic Background: Not Specified

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: En1tm1(Wnt1)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: B6.129S2-Cd28tm1Mak

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(Cd4-cre)1Cwi/?,Traf6tm2Ywc/Traf6tm2Ywc
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * NOD

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Cd28tm1Ltu/Cd28tm1Ltu,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: NOD.129S2-Cd28tm1Mak

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: NOD.129S2-Cd28tm1Mak

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(Cd4-cre)1Cwi/?,Traf6tm2Ywc/Traf6tm2Ywc
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

Allelic Composition: Cd28tm1a(EUCOMM)Hmgu/Cd28tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cd28tm1a(EUCOMM)Hmgu/H

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Cd28tm1Jmg/Cd28tm1Jmg
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Jmg
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cd28tm1Jmg/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(Cd4-cre)1Cwi/?,Traf6tm2Ywc/Traf6tm2Ywc
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

Allelic Composition: Cd28tm1Jmg/Cd28tm1Jmg
Genetic Background: B6.129X1-Cd28tm1Jmg

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0008747 abnormal T cell anergy "any anomaly in the process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction" [GO:0002870]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6JSfdAnu

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr