ENSGALG00000008669


Gallus gallus

Features
Gene ID: ENSGALG00000008669
  
Biological name :CD28
  
Synonyms : CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog
  
Possible biological names infered from orthology : CD28 molecule / P10747 / P31041 / T-cell-specific surface glycoprotein CD28
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 13495614
Gene end: 13507829
  
Corresponding Affymetrix probe sets: Gga.723.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014099
NCBI entrez gene - 396249     See in Manteia.
RefSeq - NM_205311
RefSeq Peptide - NP_990642
swissprot - P31043
Ensembl - ENSGALG00000008669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD28ENSG00000178562Homo sapiens
 Cd28ENSMUSG00000026012Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTLA4 / cytotoxic T-lymphocyte associated protein 4 / P16410*ENSGALG0000000866627


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR008093  T cell antigen CD28
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002863 positive regulation of inflammatory response to antigenic stimulus IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0045066 regulatory T cell differentiation IEA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044214 spanning component of plasma membrane ISS
 cellular_componentGO:0098636 protein complex involved in cell adhesion IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / reaction
 ENSGALG00000008669 CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog / P31041* / P10747* / CD28 molecule* / T-cell-specific surface glycoprotein CD28 *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex






 

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