ENSMUSG00000026011


Mus musculus

Features
Gene ID: ENSMUSG00000026011
  
Biological name :Ctla4
  
Synonyms : Ctla4 / cytotoxic T-lymphocyte associated protein 4
  
Possible biological names infered from orthology : P16410
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 60887000
Gene end: 60915832
  
Corresponding Affymetrix probe sets: 10346790 (MoGene1.0st)   1419334_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027164
Ensembl peptide - ENSMUSP00000095327
NCBI entrez gene - 12477     See in Manteia.
MGI - MGI:88556
RefSeq - NM_009843
RefSeq - NM_001281976
RefSeq Peptide - NP_001268905
RefSeq Peptide - NP_033973
swissprot - Q5SSM0
swissprot - Q6GTR6
Ensembl - ENSMUSG00000026011
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd28ENSDARG00000095070Danio rerio
 CTLA4ENSGALG00000008666Gallus gallus
 CTLA4ENSG00000163599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*ENSMUSG0000002601228


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008096  Cytotoxic T-lymphocyte antigen 4
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045590 negative regulation of regulatory T cell differentiation IEA
 biological_processGO:0050777 negative regulation of immune response IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098636 protein complex involved in cell adhesion IEA


Pathways (from Reactome)
Pathway description
CTLA4 inhibitory signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Rag1tm1Mom/Rag1tm1Mom,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Ctla4tm1Shr

Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Ctla4tm1All/Ctla4tm1All
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraTcrb)8Rest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Espl1tm1.2Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr,Rag2tm1Fwa/Rag2tm1Fwa,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Rag1tm1Mom/Rag1tm1Mom,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraTcrb)8Rest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraTcrb)8Rest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hif1atm1Pec/Hif1atm1Pec
Genetic Background: involves: 129S6/SvEvTac

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraTcrb)8Rest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

Allelic Composition: Ctla4tm1Mak/Ctla4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Ctla4tm1All/Ctla4tm1All,Rag1tm1Mom/Rag1tm1Mom,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Cd28tm1Shr/Cd28tm1Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: C.129S4-Cd28tm1Shr Ctla4tm1Shr

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ctla4tm1Saka/Ctla4tm1Saka,Foxp3tm1(cre)Saka/Y
Genetic Background: involves: BALB/c

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0010016 variable depigmentation "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraTcrb)8Rest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ctla4tm1All/Ctla4tm1All
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026011 Ctla4 / cytotoxic T-lymphocyte associated protein 4 / P16410*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / complex / reaction
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / complex / reaction






 

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