ENSMUSG00000075122


Mus musculus

Features
Gene ID: ENSMUSG00000075122
  
Biological name :Cd80
  
Synonyms : Cd80 / Q00609 / T-lymphocyte activation antigen CD80
  
Possible biological names infered from orthology : CD80 molecule / P33681
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B4
Gene start: 38458933
Gene end: 38486933
  
Corresponding Affymetrix probe sets: 10435704 (MoGene1.0st)   1427717_at (Mouse Genome 430 2.0 Array)   1432826_a_at (Mouse Genome 430 2.0 Array)   1451950_a_at (Mouse Genome 430 2.0 Array)   1454372_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097404
NCBI entrez gene - 12519     See in Manteia.
MGI - MGI:101775
RefSeq - XM_017316858
RefSeq - NM_009855
RefSeq - XM_006521737
RefSeq - XM_017316857
RefSeq Peptide - NP_033985
swissprot - Q00609
swissprot - Q549R2
Ensembl - ENSMUSG00000075122
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD80ENSGALG00000015474Gallus gallus
 CD80ENSG00000121594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*ENSMUSG0000002290121


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IGI
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098636 protein complex involved in cell adhesion ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic Background: involves: 129S4/SvJae * FVB/N * NOD

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * NOD

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic Background: involves: 129S4/SvJae * FVB/N * NOD

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic Background: involves: 129S4/SvJae * FVB/N * NOD

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr,Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
Show

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm1Shr/Cd86tm1Shr
Genetic Background: B6.129S4-Cd80tm1Shr Cd86tm1Shr

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009023 abnormal spinal cord meninges morphology "any structural anomaly in any of the membranes covering the spinal cord, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000026011 Ctla4 / cytotoxic T-lymphocyte associated protein 4 / P16410*  / complex / reaction
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / complex






 

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