ENSMUSG00000000409


Mus musculus

Features
Gene ID: ENSMUSG00000000409
  
Biological name :Lck
  
Synonyms : Lck / P06240 / Proto-onco tyrosine-protein kinase LCK
  
Possible biological names infered from orthology : LCK proto-oncogene, Src family tyrosine kinase / P06239
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 129548344
Gene end: 129573641
  
Corresponding Affymetrix probe sets: 10516620 (MoGene1.0st)   1425396_a_at (Mouse Genome 430 2.0 Array)   1439145_at (Mouse Genome 430 2.0 Array)   1439146_s_at (Mouse Genome 430 2.0 Array)   1457917_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125777
Ensembl peptide - ENSMUSP00000066209
Ensembl peptide - ENSMUSP00000099656
Ensembl peptide - ENSMUSP00000119263
NCBI entrez gene - 16818     See in Manteia.
MGI - MGI:96756
RefSeq - XM_006502818
RefSeq - NM_001162432
RefSeq - NM_001162433
RefSeq - NM_010693
RefSeq Peptide - NP_001155904
RefSeq Peptide - NP_001155905
RefSeq Peptide - NP_034823
swissprot - B2KG65
swissprot - E9Q696
swissprot - P06240
Ensembl - ENSMUSG00000000409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lckENSDARG00000102525Danio rerio
 LCKENSGALG00000000466Gallus gallus
 LCKENSG00000182866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328364
Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*ENSMUSG0000004222862
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445359
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984356
Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*ENSMUSG0000001493255
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764653
Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*ENSMUSG0000002887452
Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*ENSMUSG0000001977945
Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSMUSG0000002757937
Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*ENSMUSG0000003875134


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035749  Lck, SH3 domain
 IPR035850  Tyrosine-protein kinase Lck, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation IMP
 biological_processGO:0045589 regulation of regulatory T cell differentiation IGI
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0050856 regulation of T cell receptor signaling pathway IDA
 biological_processGO:0050870 positive regulation of T cell activation IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0042608 T cell receptor binding IEA
 molecular_functionGO:0042609 CD4 receptor binding IEA
 molecular_functionGO:0042610 CD8 receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:1990405 protein antigen binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs
Genetic Background: involves: C3H * C57BL/6

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lcktm1Mak/Lcktm1Mak,Rag1tm1Mom/Rag1+,Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lcktm1Mak/Lcktm1Mak
Genetic Background: B6.129S2-Lcktm1Mak

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lcktm1Dbs/Lcktm1Dbs
Genetic Background: involves: C3H * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lcktm1.1Litt/Lcktm1.1Litt
Genetic Background: Not Specified

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lcktm1Dbs/Lcktm1Dbs
Genetic Background: involves: C3H * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lcktm1Mak/Lcktm1Mak,Rag1tm1Mom/Rag1+,Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

Allelic Composition: Lcktm1Mak/Lcktm1Mak
Genetic Background: B6.129S2-Lcktm1Mak

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lcktm1Dbs/Lcktm1Dbs
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lcktm1Dbs/Lcktm1Dbs,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd247tm1Mal/Cd247tm1Mal,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008038 abnormal NK T cell number "deviation from the normal number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0008047 absent uterine NK cells "absence of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

Allelic Composition: Lckm2Btlr/Lckm2Btlr
Genetic Background: C57BL/6J-Lckm2Btlr

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

Allelic Composition: Lckm2Btlr/Lckm2Btlr
Genetic Background: C57BL/6J-Lckm2Btlr

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

 MP:0008081 abnormal single-positive T cell number "anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lcktm1Mak/Lcktm1Mak
Genetic Background: B6.129S2-Lcktm1Mak

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008894 abnormal intraepithelial T cell morphology "any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Lcktm1Mak/Lcktm1Mak
Genetic Background: B6.129S2-Lcktm1Mak

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Lcktm1Mak/Lcktm1Mak
Genetic Background: B6.129S2-Lcktm1Mak

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000016496 Cd274 / Q9EP73 / CD274 antigen / Q9NZQ7* / CD274 molecule*  / complex / reaction
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / reaction / complex
 ENSMUSG00000026285 Pdcd1 / Q02242 / programmed cell death 1 / Q15116*  / complex / reaction
 ENSMUSG00000023992 Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*  / complex
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / complex / reaction
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000030165 Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*  / complex
 ENSMUSG00000030149 Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000016498 Q9WUL5 / Pdcd1lg2 / programmed cell death 1 ligand 2 / Q9BQ51*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000079852 Klra4 / Q60651 / Mus musculus killer cell lectin-like receptor, subfamily A, member 18 (Klra18), mRNA.  / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / complex / reaction
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / reaction / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / reaction / complex
 ENSMUSG00000025314 Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*  / reaction






 

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