| MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas
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| MP:0001829 | increased activated T cell number | "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002376 | abnormal dendritic cell physiology | "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808] |
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr
Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0002410 | decreased susceptibility to viral infection | "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0002432 | abnormal CD4+ T cell morphology/development | "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH
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| MP:0002738 | hyperresponsive to tactile stimuli | "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski
Allelic Composition: Cd274tm1.1Lex/Cd274tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0003724 | susceptibility to induced arthritis | "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0004392 | abnormal CD8-positive T cell physiology | "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004799 | increased susceptibility to experimental autoimmune encephalomyelitis | "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1.1Lex/Cd274tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0004803 | increased susceptibility to autoimmune diabetes | "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr
Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6
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| MP:0004946 | abnormal regulatory T cell physiology | "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0005010 | abnormal CD8+ T cell morphology/development | "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH
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| MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0005026 | decreased susceptibility to parasitic infection | "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski
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| MP:0005165 | increased susceptibility to injury | "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0005348 | increased T cell proliferation | "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0005350 | increased susceptibility to autoimmune disorders | "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0006414 | decreased T cell apoptosis | "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008037 | abnormal T cell morphology | "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1.1Lex/Cd274tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0008087 | decreased T helper 1 cell number | "reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008088 | abnormal T-helper 1 cell differentiation | "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008098 | decreased plasma cell number | "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008178 | decreased germinal center B cell number | "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008495 | decreased IgG1 level | "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr
Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr
Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: C.129S-Cd274tm1Lpc
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| MP:0008568 | abnormal interleukin secretion | "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr
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| MP:0008682 | decreased interleukin-17 secretion | "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: C.129S-Cd274tm1Lpc
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| MP:0008687 | increased interleukin-2 secretion | "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: C.129S-Cd274tm1Lpc
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| MP:0008700 | decreased interleukin-4 secretion | "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr
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| MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0008896 | increased IgG2c level | "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0009790 | decreased susceptibility to viral infection induced morbidity/mortality | "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0010189 | abnormal T follicular helper cell physiology | "any functional anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: C.129S-Cd274tm1Lpc
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| MP:0010220 | decreased T-helper 17 cell number | "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899] |
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Allelic Composition: Cd274tm1Lpc/Cd274tm1Lpc
Genetic Background: C.129S-Cd274tm1Lpc
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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