Manteia - Molecule gene

ENSMUSG00000026285

Mus musculus

Features

Gene ID:	ENSMUSG00000026285

Biological name :	Pdcd1

Synonyms :	Pdcd1 / programmed cell death 1 / Q02242

Possible biological names infered from orthology :	Q15116

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	D
Gene start:	94038305
Gene end:	94052553

Corresponding Affymetrix probe sets:	10356866 (MoGene1.0st) 1449835_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000027507 NCBI entrez gene - 18566 See in Manteia. MGI - MGI:104879 RefSeq - NM_008798 RefSeq Peptide - NP_032824 swissprot - Q02242 swissprot - Q544F3 Ensembl - ENSMUSG00000026285

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000046559	Gallus gallus
PDCD1	ENSG00000188389	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR013106	Immunoglobulin V-set domain
IPR013783	Immunoglobulin-like fold
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002644	negative regulation of tolerance induction	IMP
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IMP
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0070234	positive regulation of T cell apoptotic process	IEA
cellular_component	GO:0009897	external side of plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000540	abnormal urinary bladder epithelium morphology	"malformation of the epithelial layer of the urinary bladder" [MGI:tc]	Show Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0001627	abnormal cardiac output	"anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0001654	hepatic necrosis	"pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brinp1^tm1.1Pib/Brinp1⁺ Genetic Background: involves: BALB/cJ * C57BL/6 Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0001661	extended life span	"persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Brinp1^tm1.1Pib/Brinp1⁺ Genetic Background: involves: BALB/cJ * C57BL/6 Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brinp1^tm1.1Pib/Brinp1⁺ Genetic Background: involves: BALB/cJ * C57BL/6 Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0001864	vasculitis	"inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss
MP:0001869	pancreas inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Foxp3^{tm2.1(EGFP/cre)Shori},Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0002495	increased IgA	"greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0002750	exophthalmos	"protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0002972	abnormal cardiac muscle contractility	"altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0002983	increased retinal ganglion cell number	"greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss
MP:0002993	arthritis	"joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghrl^tm1Lex/Ghrl^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0003620	decreased urine output	"decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c
MP:0004031	insulitis	"a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
MP:0004752	decreased length of allograft survival	"compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Btla^tm1Kmm/Btla^tm1Kmm,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: B6.129S-Pdcd1^tm1Hon Btla^tm1Kmm
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghrl^tm1Lex/Ghrl^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0 Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Gt(ROSA)26Sor^{tm2(Cd74)Awai}/Gt(ROSA)26Sor⁺,Il10^tm1Roer/Il10^tm1Roer Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0004803	increased susceptibility to autoimmune diabetes	"greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
MP:0004973	increased regulatory T cell number	"greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss
MP:0004974	decreased regulatory T cell number	"reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0004977	increased B-1 B cell number	"greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0004978	decreased B-1 B cell number	"reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss
MP:0005000	immune tolerance	"the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Prss21^tm1Anta/Prss21^tm1Anta Genetic Background: involves: NIH Black Swiss
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0005348	increased T cell proliferation	"increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Btla^tm1Kmm/Btla^tm1Kmm Genetic Background: B6.129S-Btla^tm1Kmm Allelic Composition: Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
MP:0005350	increased susceptibility to autoimmune disorders	"greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0005460	abnormal leukopoiesis	"anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0005671	response to transplant	"the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0008022	dilated heart ventricles	"the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghrl^tm1Lex/Ghrl^tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0008086	increased T-helper 1 cell number	"greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0008091	decreased T-helper 2 cell number	"reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0008501	increased IgG2b level	"greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0008502	increased IgG3 level	"greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit^W-42J Genetic Background: C57BL/6J-Kit^W-42J/J
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0008681	increased interleukin-17 secretion	"increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0008682	decreased interleukin-17 secretion	"reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0008687	increased interleukin-2 secretion	"increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0008713	abnormal cytokine level	"deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c
MP:0009148	pancreas necrosis	"pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0009646	urinary bladder inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c
MP:0009764	decreased sensitivity to induced morbidity/mortality	"increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fos^tm7Wag/Fos^tm7Wag,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0009828	delayed tumor appearance	"later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0010220	decreased T-helper 17 cell number	"reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]	Show Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0010857	pulmonary necrosis	"pathological cell death in the lung, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129S2/SvPas Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon,Vsir^tm1Lex/Vsir^tm1Lex Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
MP:0011887	decreased circulating lipase level	"reduced blood level of lipase in the blood, in particular the serum" [MGI:csmith]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0013295	pancreas atrophy	"acquired size diminution of any portion of the pancreas, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0013772	increased effector memory T-helper cell number	"increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000016496	Cd274 / Q9EP73 / CD274 antigen / Q9NZQ7* / CD274 molecule*	/ complex / reaction
ENSMUSG00000043733	P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ complex / reaction
ENSMUSG00000000409	Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*	/ complex / reaction
ENSMUSG00000032312	Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*	/ complex / reaction
ENSMUSG00000004266	Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*	/ reaction / complex
ENSMUSG00000016498	Q9WUL5 / Pdcd1lg2 / programmed cell death 1 ligand 2 / Q9BQ51*	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr