ENSMUSG00000016498


Mus musculus

Features
Gene ID: ENSMUSG00000016498
  
Biological name :Pdcd1lg2
  
Synonyms : Pdcd1lg2 / programmed cell death 1 ligand 2 / Q9WUL5
  
Possible biological names infered from orthology : Q9BQ51
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 29410919
Gene end: 29471157
  
Corresponding Affymetrix probe sets: 10462398 (MoGene1.0st)   1450290_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108195
NCBI entrez gene - 58205     See in Manteia.
MGI - MGI:1930125
RefSeq - NM_021396
RefSeq Peptide - NP_067371
swissprot - Q3U304
swissprot - Q9WUL5
Ensembl - ENSMUSG00000016498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-241b2.5ENSDARG00000100899Danio rerio
 PDCD1LG2ENSGALG00000031794Gallus gallus
 Q9BQ51ENSG00000197646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd274 / Q9EP73 / CD274 antigen / Q9NZQ7* / CD274 molecule*ENSMUSG0000001649632


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IDA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PD-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Viptm1Clw/Vip+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd274tm1.1Lex/Cd274tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr
Genetic Background: C.B6-Cd274tm1Shr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
Genetic Background: C.B6-Cd274tm1Shr Pdcd1lg2tm3Shr

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000026285 Pdcd1 / Q02242 / programmed cell death 1 / Q15116*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex






 

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