ENSG00000197646


Homo sapiens

Features
Gene ID: ENSG00000197646
  
Biological name :PDCD1LG2
  
Synonyms : PDCD1LG2 / programmed cell death 1 ligand 2 / Q9BQ51
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p24.1
Gene start: 5510570
Gene end: 5571254
  
Corresponding Affymetrix probe sets: 220049_s_at (Human Genome U133 Plus 2.0 Array)   224399_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380855
NCBI entrez gene - 80380     See in Manteia.
OMIM - 605723
RefSeq - NM_025239
RefSeq - XM_005251600
RefSeq Peptide - NP_079515
swissprot - Q9BQ51
Ensembl - ENSG00000197646
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-241b2.5ENSDARG00000100899Danio rerio
 PDCD1LG2ENSGALG00000031794Gallus gallus
 Q9WUL5ENSMUSG00000016498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD274 / Q9NZQ7 / CD274 moleculeENSG0000012021734


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response NAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032693 negative regulation of interleukin-10 production IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
PD-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000188389 PDCD1 / Q15116 / programmed cell death 1  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex






 

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