ENSG00000188389


Homo sapiens

Features
Gene ID: ENSG00000188389
  
Biological name :PDCD1
  
Synonyms : PDCD1 / programmed cell death 1 / Q15116
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.3
Gene start: 241849881
Gene end: 241858908
  
Corresponding Affymetrix probe sets: 207634_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000335062
Ensembl peptide - ENSP00000390296
Ensembl peptide - ENSP00000340808
NCBI entrez gene - 5133     See in Manteia.
OMIM - 600244
RefSeq - XM_017004293
RefSeq - NM_005018
RefSeq Peptide - NP_005009
swissprot - H0Y2W6
swissprot - E7ER21
swissprot - Q15116
swissprot - A0A0M3M0G7
Ensembl - ENSG00000188389
  
Related genetic diseases (OMIM): 126200 - {Multiple sclerosis, disease progression, modifier of}, 126200
  605218 - {Systemic lupus erythematosus, susceptibility to, 2}, 605218
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000046559Gallus gallus
 Pdcd1ENSMUSG00000026285Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002644 negative regulation of tolerance induction IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0070234 positive regulation of T cell apoptotic process IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PD-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000120217 CD274 / Q9NZQ7 / CD274 molecule  / complex / reaction
 ENSG00000197646 Q9BQ51 / PDCD1LG2 / programmed cell death 1 ligand 2  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex






 

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