ENSMUSG00000032312


Mus musculus

Features
Gene ID: ENSMUSG00000032312
  
Biological name :Csk
  
Synonyms : Csk / P41241 / Tyrosine-protein kinase CSK
  
Possible biological names infered from orthology : C-terminal Src kinase / P41240
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 57626646
Gene end: 57653631
  
Corresponding Affymetrix probe sets: 10593966 (MoGene1.0st)   1423518_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149308
Ensembl peptide - ENSMUSP00000150984
Ensembl peptide - ENSMUSP00000150590
Ensembl peptide - ENSMUSP00000150240
Ensembl peptide - ENSMUSP00000034863
Ensembl peptide - ENSMUSP00000149143
NCBI entrez gene - 12988     See in Manteia.
MGI - MGI:88537
RefSeq - XM_006510801
RefSeq - XM_011242659
RefSeq - XM_006510802
RefSeq - NM_001304761
RefSeq - NM_007783
RefSeq Peptide - NP_001291690
RefSeq Peptide - NP_031809
swissprot - P41241
swissprot - A0A1L1STA1
swissprot - A0A1L1SQQ5
swissprot - A0A1L1SR46
Ensembl - ENSMUSG00000032312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cskENSDARG00000067996Danio rerio
 CSKENSGALG00000031270Gallus gallus
 CSKENSG00000103653Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493352
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659641
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684240
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921737
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489236
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126435
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039534
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315834
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137734
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012734


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035026  Tyrosine-protein kinase CSK
 IPR035027  CSK-like, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IBA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0034332 adherens junction organization IBA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042997 negative regulation of Golgi to plasma membrane protein transport ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050863 regulation of T cell activation TAS
 biological_processGO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway IBA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity TAS
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070064 proline-rich region binding IEA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains
Integrin alphaIIb beta3 signaling
PD-1 signaling
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001288 abnormal lens induction "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Ptprcltng/Ptprcltng
Genetic Background: C57BL/6-Ptprcltng

Allelic Composition: Csktm1Sor/Csk+,Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csktm1Sor/Csk+,Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0006293 absent olfactory placodes "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Csktm1Sor/Csktm1Sor
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0012170 absent optic placodes "absence of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [MGI:anna]
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Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0012707 incomplete caudal neuropore closure "incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed" [MGI:anna]
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Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Cryget/Cryge+
Genetic Background: involves: 102/El * C3H/El * T-stock

Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016496 Cd274 / Q9EP73 / CD274 antigen / Q9NZQ7* / CD274 molecule*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction / complex
 ENSMUSG00000026285 Pdcd1 / Q02242 / programmed cell death 1 / Q15116*  / complex / reaction
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction / complex
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000016498 Q9WUL5 / Pdcd1lg2 / programmed cell death 1 ligand 2 / Q9BQ51*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000027508 Pag1 / Q3U1F9 / phosphoprotein associated with glycosphingolipid microdomains 1 / Q9NWQ8* / phosphoprotein membrane anchor with glycosphingolipid microdomains 1*  / reaction / complex






 

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