ENSMUSG00000027508


Mus musculus

Features
Gene ID: ENSMUSG00000027508
  
Biological name :Pag1
  
Synonyms : Pag1 / phosphoprotein associated with glycosphingolipid microdomains 1 / Q3U1F9
  
Possible biological names infered from orthology : phosphoprotein membrane anchor with glycosphingolipid microdomains 1 / Q9NWQ8
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 9687479
Gene end: 9833679
  
Corresponding Affymetrix probe sets: 10497237 (MoGene1.0st)   1423002_at (Mouse Genome 430 2.0 Array)   1436570_at (Mouse Genome 430 2.0 Array)   1443319_at (Mouse Genome 430 2.0 Array)   1456403_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104021
Ensembl peptide - ENSMUSP00000124529
NCBI entrez gene - 94212     See in Manteia.
MGI - MGI:2443160
RefSeq - XM_011248151
RefSeq - NM_001195031
RefSeq - NM_053182
RefSeq - XM_006530107
RefSeq Peptide - NP_444412
RefSeq Peptide - NP_001181960
swissprot - Q3U1F9
swissprot - A6H659
Ensembl - ENSMUSG00000027508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pag1ENSDARG00000055875Danio rerio
 PAG1ENSGALG00000034188Gallus gallus
 PAG1ENSG00000076641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR032748  Phosphoprotein associated with glycosphingolipid-enriched microdomains 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0050863 regulation of T cell activation TAS
 biological_processGO:0050868 negative regulation of T cell activation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft TAS
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042169 SH2 domain binding IBA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3.1Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex / reaction






 

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