ENSG00000076641


Homo sapiens

Features
Gene ID: ENSG00000076641
  
Biological name :PAG1
  
Synonyms : PAG1 / phosphoprotein membrane anchor with glycosphingolipid microdomains 1 / Q9NWQ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q21.13
Gene start: 80967810
Gene end: 81112068
  
Corresponding Affymetrix probe sets: 225622_at (Human Genome U133 Plus 2.0 Array)   225626_at (Human Genome U133 Plus 2.0 Array)   227354_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000220597
NCBI entrez gene - 55824     See in Manteia.
OMIM - 605767
RefSeq - XM_017013643
RefSeq - NM_018440
RefSeq - XM_017013641
RefSeq - XM_017013642
RefSeq - XM_017013640
RefSeq Peptide - NP_060910
swissprot - Q9NWQ8
Ensembl - ENSG00000076641
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pag1ENSDARG00000055875Danio rerio
 PAG1ENSGALG00000034188Gallus gallus
 Pag1ENSMUSG00000027508Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR032748  Phosphoprotein associated with glycosphingolipid-enriched microdomains 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050863 regulation of T cell activation IDA
 biological_processGO:0050868 negative regulation of T cell activation IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042169 SH2 domain binding IDA


Pathways (from Reactome)
Pathway description
GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction






 

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