ENSMUSG00000021823


Mus musculus

Features
Gene ID: ENSMUSG00000021823
  
Biological name :Vcl
  
Synonyms : Q64727 / Vcl / vinculin
  
Possible biological names infered from orthology : P18206
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 20929398
Gene end: 21033676
  
Corresponding Affymetrix probe sets: 10413059 (MoGene1.0st)   1416156_at (Mouse Genome 430 2.0 Array)   1416157_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153447
Ensembl peptide - ENSMUSP00000022369
NCBI entrez gene - 22330     See in Manteia.
MGI - MGI:98927
RefSeq - NM_009502
RefSeq - XM_006518922
RefSeq Peptide - NP_033528
swissprot - A0A286YDJ4
swissprot - Q64727
Ensembl - ENSMUSG00000021823
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vclaENSDARG00000098695Danio rerio
 vclaENSDARG00000044968Danio rerio
 VCLENSGALG00000005079Gallus gallus
 VCLENSG00000035403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctnna1 / P26231 / Catenin alpha-1 / P35221*ENSMUSG0000003781520
Ctnna2 / Q61301 / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA. / P26232* / catenin alpha 2*ENSMUSG0000006306320
Ctnna3 / Q65CL1 / Catenin alpha-3 / Q9UI47*ENSMUSG0000006084318
O88327 / Ctnnal1 / Alpha-catulin / Q9UBT7* / catenin alpha like 1*ENSMUSG0000003881611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR006077  Vinculin/alpha-catenin
 IPR017997  Vinculin
 IPR036723  Alpha-catenin/vinculin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030032 lamellipodium assembly IDA
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0034333 adherens junction assembly IEA
 biological_processGO:0034394 protein localization to cell surface IEA
 biological_processGO:0043297 apical junction assembly IEA
 biological_processGO:0048675 axon extension IGI
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005903 brush border ISS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005915 zonula adherens ISS
 cellular_componentGO:0005916 fascia adherens IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0090636 outer dense plaque of desmosome ISS
 cellular_componentGO:0090637 inner dense plaque of desmosome ISS
 cellular_componentGO:1990357 terminal web ISS
 molecular_functionGO:0002162 dystroglycan binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0045294 alpha-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Smooth Muscle Contraction
MAP2K and MAPK activation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apptm3.2Umu/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

 MP:0010559 heart block "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0012250 absent heart valves "failure to form all of the membranous folds of the heart that prevent reflux of fluid" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0012677 absent brain ventricles "absence of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Vcltm1.1Whz/Vcltm1.1Whz
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0013164 abnormal forelimb bud morphology "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0013166 small forelimb buds "reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0013227 small brain ventricles "decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex






 

1 s.

 
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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr