ENSDARG00000098695


Danio rerio

Features
Gene ID: ENSDARG00000098695
  
Biological name :vcla
  
Synonyms : vcla / vinculin a
  
Possible biological names infered from orthology : P18206 / Q64727 / VCL / vinculin
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 46791907
Gene end: 46835940
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000100647
NCBI entrez gene - 100334859     See in Manteia.
RefSeq - NM_001317752
RefSeq Peptide - NP_001304681
swissprot - B3DI32
ZFIN ID - ZDB-GENE-050506-61
Ensembl - ENSDARG00000098695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VCLENSGALG00000005079Gallus gallus
 VCLENSG00000035403Homo sapiens
 VclENSMUSG00000021823Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*ENSDARG0000004496886
ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*ENSDARG0000010244119
B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...ENSDARG0000002478518
ctnnal1 / catenin (cadherin-associated protein), alpha-like 1 / O88327* / Q9UBT7* / Alpha-catulin * / catenin alpha like 1*ENSDARG000000181628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR006077  Vinculin/alpha-catenin
 IPR017997  Vinculin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential IMP
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Smooth Muscle Contraction
MAP2K and MAPK activation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart decreased contractility , abnormal
heart decreased functionality , abnormal
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 ZFA:0000154 sinus venosus sinus venosus increased accumulation blood , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle sarcomere decreased thickness , abnormal
skeletal muscle Z disc increased width , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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