ENSMUSG00000031264


Mus musculus

Features
Gene ID: ENSMUSG00000031264
  
Biological name :Btk
  
Synonyms : Btk / P35991 / Tyrosine-protein kinase BTK
  
Possible biological names infered from orthology : Bruton tyrosine kinase / Q06187
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E3
Gene start: 134542336
Gene end: 134583570
  
Corresponding Affymetrix probe sets: 10606694 (MoGene1.0st)   1422755_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033617
Ensembl peptide - ENSMUSP00000108839
NCBI entrez gene - 12229     See in Manteia.
MGI - MGI:88216
RefSeq - XM_006528485
RefSeq - NM_013482
RefSeq - XM_006528483
RefSeq - XM_006528484
RefSeq Peptide - NP_038510
swissprot - A2BDW0
swissprot - P35991
Ensembl - ENSMUSG00000031264
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 btkENSDARG00000004433Danio rerio
 BTKENSGALG00000004958Gallus gallus
 BTKENSG00000010671Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921753
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039549
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137748
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489240
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684231
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659631
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012727
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315826
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231224
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035574  Tyrosine-protein kinase BTK, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001805 positive regulation of type III hypersensitivity IEA
 biological_processGO:0001812 positive regulation of type I hypersensitivity IEA
 biological_processGO:0001818 negative regulation of cytokine production IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002344 B cell affinity maturation IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002553 histamine secretion by mast cell IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0071226 cellular response to molecule of fungal origin IEA
 biological_processGO:0098761 cellular response to interleukin-7 IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
RHO GTPases Activate WASPs and WAVEs
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000549 absent limbs "missing extremities" [J:51966, J:50768]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: involves: CBA/HN * DBA/2N

Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

Allelic Composition: Btktm1a(EUCOMM)Hmgu/Y
Genetic Background: C57BL/6N-Btktm1a(EUCOMM)Hmgu/Ics

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Allelic Composition: Btkxid/?
Genetic Background: involves: BALB/c * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

Allelic Composition: Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btkxid/Btkxid
Genetic Background: involves: CBA/HN * DBA/2N

Allelic Composition: Blnktm1Achn/Blnk+,Btktm1Wk/Btktm1Wk,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Allelic Composition: Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

Allelic Composition: Btkm2Anu/Btkm2Anu
Genetic Background: C57BL/6NCrlAnu-Btkm2Anu

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btkxid/?
Genetic Background: involves: BALB/c * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btkxid/Y
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Btkxid/Btkxid
Genetic Background: involves: CBA/HN * DBA/2N

Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Btktm1Gsv/Btk+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Btkvila/Btkvila
Genetic Background: C57BL/6JAnu-Btkvila/Apb

Allelic Composition: Btkm1Anu/Btkm1Anu,X/Yaa
Genetic Background: involves: BXSB/MpJ * C57BL/6JAnu * SB/Le

Allelic Composition: Btkm1Anu/Btkm1Anu
Genetic Background: involves: BXSB/MpJ * C57BL/6JAnu * SB/Le

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btkxid/Y
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Btkxid/Y
Genetic Background: involves: CBA/HN * DBA/2N

Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Blnktm1Achn/Blnk+,Btktm1Wk/Btktm1Wk,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

Allelic Composition: Btkxid/?
Genetic Background: involves: BALB/c * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: involves: CBA/HN * DBA/2N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1a(EUCOMM)Hmgu/Y
Genetic Background: C57BL/6N-Btktm1a(EUCOMM)Hmgu/Ics

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btkxid/Btkxid,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mycntm1Psk/Mycntm1Psk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008203 absent B-1a cells "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Gsv/Btk+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Gsv/Btk+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Btkxid/?
Genetic Background: involves: BALB/c * CBA/N

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btkm2Anu/Btkm2Anu
Genetic Background: C57BL/6NCrlAnu-Btkm2Anu

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Btkvila/Btkvila
Genetic Background: C57BL/6JAnu-Btkvila/Apb

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Allelic Composition: Btkxid/?
Genetic Background: involves: BALB/c * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btkxid/Y
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction






 

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