Manteia - Molecule gene

ENSMUSG00000002699

Mus musculus

Features

Gene ID:	ENSMUSG00000002699

Biological name :	Lcp2

Synonyms :	Lcp2 / Lymphocyte cytosolic protein 2 / Q60787

Possible biological names infered from orthology :	Q13094

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A4
Gene start:	34046920
Gene end:	34092295

Corresponding Affymetrix probe sets:	10375145 (MoGene1.0st) 1418641_at (Mouse Genome 430 2.0 Array) 1418642_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000104952 Ensembl peptide - ENSMUSP00000056621 NCBI entrez gene - 16822 See in Manteia. MGI - MGI:1321402 RefSeq - NM_010696 RefSeq Peptide - NP_034826 swissprot - B1ATD1 swissprot - Q60787 Ensembl - ENSMUSG00000002699

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lcp2a	ENSDARG00000055955	Danio rerio
LCP2	ENSGALG00000002113	Gallus gallus
LCP2	ENSG00000043462	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Blnk / Q9QUN3 / B-cell linker protein / Q8WV28* / B cell linker*	ENSMUSG00000061132	19
Clnk / Q9QZE2 / Cytokine-dependent hematopoietic cell linker / Q7Z7G1*	ENSMUSG00000039315	17
Sh2d6 / Q7Z4S9* / SH2 domain containing 6*	ENSMUSG00000052631	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR001660	Sterile alpha motif domain
IPR013761	Sterile alpha motif/pointed domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006955	immune response	IBA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0035556	intracellular signal transduction	IBA
biological_process	GO:0045576	mast cell activation	IMP
biological_process	GO:0045860	positive regulation of protein kinase activity	IEA
biological_process	GO:0050663	cytokine secretion	IMP
biological_process	GO:0050852	T cell receptor signaling pathway	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005911	cell-cell junction	IDA
cellular_component	GO:0036398	TCR signalosome	IEA
cellular_component	GO:0044853	plasma membrane raft	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

Generation of second messenger molecules

DAP12 signaling

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lcp2^tm1Gak/Lcp2^tm2Gak,Tg(Pf4-icre)Q3Rsko/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Tor1a^tm1Wtd/Tor1a^tm2Wtd Genetic Background: involves: 129S1/Sv Allelic Composition: Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb Allelic Composition: Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lat^tm1Les/Lat^tm1Les,Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kit^W-19H/Kit⁺,X/Sry^AKR/J Genetic Background: involves: AKR/J * C57BL/6J Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001844	autoimmune response	"condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0001879	abnormal lymphatic vessel morphology	"malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lcp2^tm1Gak/Lcp2^tm2Gak,Tg(Pf4-icre)Q3Rsko/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lcp2^tm1Gak/Lcp2^tm2Gak,Tg(Vav1-cre)1Graf/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz,Tg(TcraH-Y,TcrbH-Y)71Vbo/0 Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J Allelic Composition: Grap2^tm1Amch/Grap2^tm1Amch,Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kit^W-19H/Kit⁺,X/Sry^AKR/J Genetic Background: involves: AKR/J * C57BL/6J Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0002408	abnormal double-positive T cell	"anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb
MP:0002435	abnormal effector T cell morphology/development	"anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb
MP:0002497	increased IgE	"greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0003288	intestinal edema	"an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Lcp2^tm1Gak/Lcp2^tm2Gak,Tg(Vav1-cre)1Graf/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003850	abnormal thymocyte activation/response	"anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak,Tg(TcrAND)53Hed/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003944	abnormal T cell subpopulation ratio	"deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Kit^W-19H/Kit⁺,X/Sry^AKR/J Genetic Background: involves: AKR/J * C57BL/6J Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0004918	abnormal negative T cell selection	"any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak,Tg(TcraH-Y,TcrbH-Y)71Vbo/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2J Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak,Tg(TcraH-Y,TcrbH-Y)71Vbo/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N
MP:0004919	abnormal positive T cell selection	"any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak,Tg(TcrAND)53Hed/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak,Tg(TcrAND)53Hed/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zap70^mur/Zap70^mur Genetic Background: C57BL/6Apb-Zap70^mur/Apb Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0005070	defective NK cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo Allelic Composition: Lcp2^tm1Geha/Lcp2^tm1Geha Genetic Background: involves: 129S4/SvJae Allelic Composition: Lcp2^m1Khoe/Lcp2^m1Khoe Genetic Background: C57BL/6J-Lcp2^m1Khoe
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak,Tg(TcraH-Y,TcrbH-Y)71Vbo/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lat^tm1Les/Lat^tm1Les,Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Grap2^tm1Amch/Grap2^tm1Amch,Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0006298	abnormal platelet activation	"anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ Allelic Composition: Lcp2^tm1Gak/Lcp2^tm2Gak,Tg(Pf4-icre)Q3Rsko/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006414	decreased T cell apoptosis	"decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tor1a^tm1Wtd/Tor1a^tm2Wtd Genetic Background: involves: 129S1/Sv
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Lcp2^tm4Gak/Lcp2^tm4Gak Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0008044	increased NK cell number	"greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo Allelic Composition: Lcp2^tm1Geha/Lcp2^tm1Geha Genetic Background: involves: 129S4/SvJae
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tor1a^tm1Wtd/Tor1a^tm2Wtd Genetic Background: involves: 129S1/Sv Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz Allelic Composition: Grap2^tm1Amch/Grap2^tm1Amch,Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tor1a^tm1Wtd/Tor1a^tm2Wtd Genetic Background: involves: 129S1/Sv Allelic Composition: Lcp2^tm3Gak/Lcp2^tm3Gak,Tg(TcraH-Y,TcrbH-Y)71Vbo/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2J
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz Allelic Composition: Grap2^tm1Amch/Grap2^tm1Amch,Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Grap2^tm1Amch/Grap2^tm1Amch,Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008101	lymph node hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Tor1a^tm1Wtd/Tor1a^tm2Wtd Genetic Background: involves: 129S1/Sv
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo Allelic Composition: Lcp2^tm1Geha/Lcp2^tm1Geha Genetic Background: involves: 129S4/SvJae
MP:0008688	decreased interleukin-2 secretion	"reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Genetic Background: B6.Cg-Lcp2^tm1.1Wz
MP:0009549	impaired platelet aggregation	"decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0010766	abnormal NK cell physiology	"any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]	Show Allelic Composition: Lcp2^m1Khoe/Lcp2^m1Khoe Genetic Background: C57BL/6J-Lcp2^m1Khoe
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Cbl^tm1.1Hua/Cbl^tm1.1Hua,Lcp2^tm1Gak/Lcp2^tm1Gak Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000002033	Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*	/ reaction
ENSMUSG00000005763	Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*	/ reaction
ENSMUSG00000034116	Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*	/ complex / reaction
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ complex / reaction
ENSMUSG00000016933	Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*	/ complex / reaction
ENSMUSG00000020395	Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*	/ complex / reaction
ENSMUSG00000026117	Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*	/ reaction
ENSMUSG00000023274	Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*	/ reaction
ENSMUSG00000022781	Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*	/ reaction / complex
ENSMUSG00000036594	H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...	/ reaction
ENSMUSG00000031284	Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*	/ complex / reaction
ENSMUSG00000042626	Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*	/ reaction / complex
ENSMUSG00000031264	Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*	/ reaction / complex
ENSMUSG00000030403	Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*	/ complex / reaction
ENSMUSG00000032094	Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*	/ reaction
ENSMUSG00000073421	H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...	/ reaction
ENSMUSG00000030742	Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*	/ complex / reaction
ENSMUSG00000042351	Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*	/ reaction / complex
ENSMUSG00000030774	Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*	/ reaction / complex
ENSMUSG00000024241	Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*	/ complex / reaction
ENSMUSG00000067341	H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*	/ reaction
ENSMUSG00000009621	Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*	/ complex / reaction
ENSMUSG00000021457	Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*	/ reaction
ENSMUSG00000033721	Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*	/ reaction / complex
ENSMUSG00000000409	Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*	/ reaction
ENSMUSG00000034330	Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*	/ complex / reaction
ENSMUSG00000032475	Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*	/ reaction / complex
ENSMUSG00000002699	Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*	/ reaction
ENSMUSG00000031165	Was / P70315 / Wiskott-Aldrich syndrome / P42768*	/ complex / reaction
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ reaction / complex
ENSMUSG00000022148	Fyb / O35601 / FYN-binding protein 1 / FYB1* / O15117*	/ complex / reaction
ENSMUSG00000022995	Enah / Q03173 / ENAH, actin regulator / Q8N8S7*	/ complex / reaction
ENSMUSG00000060586	H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*	/ reaction
ENSMUSG00000032093	Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr