ENSMUSG00000022148


Mus musculus

Features
Gene ID: ENSMUSG00000022148
  
Biological name :Fyb
  
Synonyms : Fyb / FYN-binding protein 1 / O35601
  
Possible biological names infered from orthology : FYB1 / O15117
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 6522853
Gene end: 6663313
  
Corresponding Affymetrix probe sets: 10380551 (MoGene1.0st)   10422760 (MoGene1.0st)   10422776 (MoGene1.0st)   1417053_at (Mouse Genome 430 2.0 Array)   1452117_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087947
Ensembl peptide - ENSMUSP00000123895
Ensembl peptide - ENSMUSP00000153970
Ensembl peptide - ENSMUSP00000154585
NCBI entrez gene - 23880     See in Manteia.
MGI - MGI:1346327
RefSeq - XM_011245330
RefSeq - XM_006519983
RefSeq - XM_006519985
RefSeq - XM_006519986
RefSeq - XM_011245328
RefSeq - XM_011245329
RefSeq - NM_001278269
RefSeq - NM_011815
RefSeq - XM_006519982
RefSeq Peptide - NP_001265198
RefSeq Peptide - NP_035945
swissprot - F6V072
swissprot - O35601
swissprot - B2RUR0
Ensembl - ENSMUSG00000022148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fybaENSDARG00000094764Danio rerio
 fybbENSDARG00000044694Danio rerio
 FYBENSGALG00000003792Gallus gallus
 FYB1ENSG00000082074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pram1 / Q6BCL1 / PML-RARA-regulated adapter molecule 1 / Q96QH2* / PML-RARA regulated adaptor molecule 1*ENSMUSG0000003273915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR029294  Helically-extended SH3 domain
 IPR030635  FYN-binding protein
 IPR035540  FYB, helically extended SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Signal regulatory protein family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030403 Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000055447 Cd47 / Q61735 / Leukocyte surface antigen CD47 / Q08722* / CD47 molecule*  / reaction / complex
 ENSMUSG00000022995 Enah / Q03173 / ENAH, actin regulator / Q8N8S7*  / reaction / complex
 ENSMUSG00000059182 Skap2 / Q3UND0 / Src kinase-associated phosphoprotein 2 / O75563*  / reaction / complex






 

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