ENSMUSG00000059182


Mus musculus

Features
Gene ID: ENSMUSG00000059182
  
Biological name :Skap2
  
Synonyms : Q3UND0 / Skap2 / Src kinase-associated phosphoprotein 2
  
Possible biological names infered from orthology : O75563
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 51857422
Gene end: 52012549
  
Corresponding Affymetrix probe sets: 10544732 (MoGene1.0st)   1418895_at (Mouse Genome 430 2.0 Array)   1457097_at (Mouse Genome 430 2.0 Array)   1460623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145275
Ensembl peptide - ENSMUSP00000145462
Ensembl peptide - ENSMUSP00000077342
NCBI entrez gene - 54353     See in Manteia.
MGI - MGI:1889206
RefSeq - NM_018773
RefSeq Peptide - NP_061243
swissprot - A0A0N4SVW8
swissprot - Q3UND0
Ensembl - ENSMUSG00000059182
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skap2ENSDARG00000000906Danio rerio
 SKAP2ENSGALG00000030081Gallus gallus
 SKAP2ENSG00000005020Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Skap1 / Q3UUV5 / src family associated phosphoprotein 1 / Q86WV1* / src kinase associated phosphoprotein 1*ENSMUSG0000005705835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002757 immune response-activating signal transduction IBA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0042113 B cell activation IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Signal regulatory protein family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Zbtb20tm1Stoy/Zbtb20tm1Stoy
Genetic Background: involves: 129S2/SvPas

 MP:0012319 fast extinction of fear memory "enhanced ability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
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Allelic Composition: Rbl1tm1Mru/Rbl1tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055447 Cd47 / Q61735 / Leukocyte surface antigen CD47 / Q08722* / CD47 molecule*  / complex / reaction
 ENSMUSG00000022148 Fyb / O35601 / FYN-binding protein 1 / FYB1* / O15117*  / reaction / complex






 

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