ENSMUSG00000057058


Mus musculus

Features
Gene ID: ENSMUSG00000057058
  
Biological name :Skap1
  
Synonyms : Q3UUV5 / Skap1 / src family associated phosphoprotein 1
  
Possible biological names infered from orthology : Q86WV1 / src kinase associated phosphoprotein 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96464593
Gene end: 96759130
  
Corresponding Affymetrix probe sets: 10380672 (MoGene1.0st)   1437249_at (Mouse Genome 430 2.0 Array)   1440782_at (Mouse Genome 430 2.0 Array)   1441322_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103289
Ensembl peptide - ENSMUSP00000099443
Ensembl peptide - ENSMUSP00000103290
Ensembl peptide - ENSMUSP00000071445
Ensembl peptide - ENSMUSP00000098088
Ensembl peptide - ENSMUSP00000098090
NCBI entrez gene - 78473     See in Manteia.
MGI - MGI:1925723
RefSeq - XM_017314839
RefSeq - NM_001033186
RefSeq - NM_001177898
RefSeq - NM_001177899
RefSeq - XM_006534508
RefSeq - XM_017314838
RefSeq Peptide - NP_001171370
RefSeq Peptide - NP_001171369
RefSeq Peptide - NP_001028358
swissprot - B1AQX1
swissprot - Q3U5H2
swissprot - B1AQX5
swissprot - Q3UUV5
Ensembl - ENSMUSG00000057058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skap1ENSDARG00000001498Danio rerio
 SKAP1ENSGALG00000027305Gallus gallus
 SKAP1ENSG00000141293Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Skap2 / Q3UND0 / Src kinase-associated phosphoprotein 2 / O75563*ENSMUSG0000005918235


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035765  Src kinase-associated phosphoprotein 1, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002757 immune response-activating signal transduction IBA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050852 T cell receptor signaling pathway ISO
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042101 T cell receptor complex IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0042169 SH2 domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grm7tm1Betz/Grm7tm1Betz
Genetic Background: B6.129P2-Grm7tm1Betz

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm7tm1Betz/Grm7tm1Betz
Genetic Background: B6.129P2-Grm7tm1Betz

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grm7tm1Betz/Grm7tm1Betz
Genetic Background: B6.129P2-Grm7tm1Betz

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grm7tm1Betz/Grm7tm1Betz
Genetic Background: B6.129P2-Grm7tm1Betz

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Grm7tm1Betz/Grm7tm1Betz
Genetic Background: B6.129P2-Grm7tm1Betz

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Grm7tm1Betz/Grm7tm1Betz
Genetic Background: B6.129P2-Grm7tm1Betz

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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