ENSG00000005020


Homo sapiens

Features
Gene ID: ENSG00000005020
  
Biological name :SKAP2
  
Synonyms : O75563 / SKAP2 / src kinase associated phosphoprotein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p15.2
Gene start: 26667062
Gene end: 26995239
  
Corresponding Affymetrix probe sets: 204361_s_at (Human Genome U133 Plus 2.0 Array)   204362_at (Human Genome U133 Plus 2.0 Array)   216899_s_at (Human Genome U133 Plus 2.0 Array)   217035_at (Human Genome U133 Plus 2.0 Array)   217260_x_at (Human Genome U133 Plus 2.0 Array)   225639_at (Human Genome U133 Plus 2.0 Array)   241331_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000408163
Ensembl peptide - ENSP00000005587
NCBI entrez gene - 8935     See in Manteia.
OMIM - 605215
RefSeq - XM_017012771
RefSeq - NM_001303468
RefSeq - NM_003930
RefSeq Peptide - NP_001290397
RefSeq Peptide - NP_003921
swissprot - O75563
swissprot - C9JQ17
Ensembl - ENSG00000005020
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skap2ENSDARG00000000906Danio rerio
 SKAP2ENSGALG00000030081Gallus gallus
 Skap2ENSMUSG00000059182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SKAP1 / Q86WV1 / src kinase associated phosphoprotein 1ENSG0000014129335


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002757 immune response-activating signal transduction IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signal regulatory protein family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196776 CD47 / Q08722 / CD47 molecule  / complex / reaction
 ENSG00000198053 SIRPA / P78324 / signal regulatory protein alpha  / complex / reaction
 ENSG00000082074 FYB1 / O15117 / FYN binding protein 1  / reaction / complex






 

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