ENSG00000198053


Homo sapiens

Features
Gene ID: ENSG00000198053
  
Biological name :SIRPA
  
Synonyms : P78324 / signal regulatory protein alpha / SIRPA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p13
Gene start: 1894167
Gene end: 1940592
  
Corresponding Affymetrix probe sets: 202895_s_at (Human Genome U133 Plus 2.0 Array)   202896_s_at (Human Genome U133 Plus 2.0 Array)   202897_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000348307
Ensembl peptide - ENSP00000351621
Ensembl peptide - ENSP00000382941
Ensembl peptide - ENSP00000478763
NCBI entrez gene - 140885     See in Manteia.
OMIM - 602461
RefSeq - XM_011529173
RefSeq - NM_001040022
RefSeq - NM_001040023
RefSeq - NM_001330728
RefSeq - NM_080792
RefSeq - XM_005260669
RefSeq - XM_005260670
RefSeq - XM_006723545
RefSeq Peptide - NP_001035111
RefSeq Peptide - NP_001035112
RefSeq Peptide - NP_001317657
RefSeq Peptide - NP_542970
swissprot - P78324
Ensembl - ENSG00000198053
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Gm5150ENSMUSG00000078780Mus musculus
 Gm9733ENSMUSG00000078783Mus musculus
 SirpaENSMUSG00000037902Mus musculus
 Sirpb1aENSMUSG00000095788Mus musculus
 Sirpb1bENSMUSG00000095028Mus musculus
 Sirpb1cENSMUSG00000074677Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00241 / Q5TFQ8 / SIRPB1 / signal regulatory protein beta 1ENSG0000010130761
SIRPG / Q9P1W8 / signal regulatory protein gammaENSG0000008901256
AL049634.2ENSG0000026086125
Q5JXA9 / SIRPB2 / signal regulatory protein beta 2ENSG0000019620916
SIRPD / Q9H106 / signal regulatory protein deltaENSG0000012590013


Protein motifs (from Interpro)
Interpro ID Name
 IPR003597  Immunoglobulin C1-set
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Signal regulatory protein family interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005020 SKAP2 / O75563 / src kinase associated phosphoprotein 2  / reaction / complex
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction / complex
 ENSG00000196776 CD47 / Q08722 / CD47 molecule  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000082074 FYB1 / O15117 / FYN binding protein 1  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000185303 Q8IWL1 / SFTPA2 / surfactant protein A2  / complex / reaction
 ENSG00000133661 SFTPD / P35247 / surfactant protein D  / reaction / complex
 ENSG00000122852 Q8IWL2 / SFTPA1 / surfactant protein A1  / complex / reaction






 

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