ENSG00000133661


Homo sapiens

Features
Gene ID: ENSG00000133661
  
Biological name :SFTPD
  
Synonyms : P35247 / SFTPD / surfactant protein D
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.3
Gene start: 79937740
Gene end: 79982614
  
Corresponding Affymetrix probe sets: 214199_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361366
Ensembl peptide - ENSP00000394325
NCBI entrez gene - 6441     See in Manteia.
OMIM - 178635
RefSeq - XM_011540088
RefSeq - NM_003019
RefSeq - XM_011540087
RefSeq Peptide - NP_003010
swissprot - Q5T0M2
swissprot - P35247
Ensembl - ENSG00000133661
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbl1ENSDARG00000068221Danio rerio
 hbl2ENSDARG00000094681Danio rerio
 hbl4ENSDARG00000054202Danio rerio
 mbl2ENSDARG00000068220Danio rerio
 SftpdENSMUSG00000021795Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MBL2 / P11226 / mannose binding lectin 2ENSG0000016547129
Q8IWL2 / SFTPA1 / surfactant protein A1ENSG0000012285227
Q8IWL1 / SFTPA2 / surfactant protein A2ENSG0000018530327
Q9BWP8 / COLEC11 / collectin subfamily member 11ENSG0000011800422
Q9Y6Z7 / COLEC10 / collectin subfamily member 10ENSG0000018437421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR008160  Collagen triple helix repeat
 IPR015097  Lung surfactant protein D coiled-coil trimerisation
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033990  Collectin, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production NAS
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0042130 negative regulation of T cell proliferation TAS
 biological_processGO:0042742 defense response to bacterium TAS
 biological_processGO:0043129 surfactant homeostasis IMP
 biological_processGO:0043152 induction of bacterial agglutination IMP
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045085 negative regulation of interleukin-2 biosynthetic process TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0048246 macrophage chemotaxis TAS
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0050766 positive regulation of phagocytosis TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0052405 negative regulation by host of symbiont molecular function IDA
 biological_processGO:0072593 reactive oxygen species metabolic process TAS
 biological_processGO:1905226 regulation of adhesion of symbiont to host epithelial cell IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0030139 endocytic vesicle TAS
 cellular_componentGO:0042599 lamellar body TAS
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding TAS
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Signal regulatory protein family interactions
Surfactant metabolism
Regulation of TLR by endogenous ligand
Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170909 OSCAR / Q8IYS5 / osteoclast associated, immunoglobulin-like receptor  / reaction / complex
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000185303 Q8IWL1 / SFTPA2 / surfactant protein A2  / reaction
 ENSG00000198053 SIRPA / P78324 / signal regulatory protein alpha  / reaction / complex
 ENSG00000187908 DMBT1 / Q9UGM3 / deleted in malignant brain tumors 1  / reaction / complex
 ENSG00000174125 TLR1 / Q15399 / toll like receptor 1  / reaction / complex
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex / reaction
 ENSG00000133661 SFTPD / P35247 / surfactant protein D  / complex / reaction / -






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr