ENSG00000137462


Homo sapiens

Features
Gene ID: ENSG00000137462
  
Biological name :TLR2
  
Synonyms : O60603 / TLR2 / toll like receptor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.3
Gene start: 153684070
Gene end: 153705702
  
Corresponding Affymetrix probe sets: 204924_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000496208
Ensembl peptide - ENSP00000495339
Ensembl peptide - ENSP00000496321
Ensembl peptide - ENSP00000496676
Ensembl peptide - ENSP00000260010
Ensembl peptide - ENSP00000493968
Ensembl peptide - ENSP00000494425
Ensembl peptide - ENSP00000494668
NCBI entrez gene - 7097     See in Manteia.
OMIM - 603028
RefSeq - XM_017008576
RefSeq - NM_001318790
RefSeq - NM_001318791
RefSeq - NM_001318793
RefSeq - NM_001318795
RefSeq - NM_001318796
RefSeq - NM_003264
RefSeq - XM_011532215
RefSeq - XM_011532216
RefSeq - XM_017008573
RefSeq - XM_017008574
RefSeq - XM_017008575
RefSeq - NM_001318787
RefSeq - NM_001318789
RefSeq Peptide - NP_001305718
RefSeq Peptide - NP_001305719
RefSeq Peptide - NP_001305720
RefSeq Peptide - NP_001305722
RefSeq Peptide - NP_001305724
RefSeq Peptide - NP_001305725
RefSeq Peptide - NP_003255
RefSeq Peptide - NP_001305716
swissprot - A0A0S2Z4L7
swissprot - A0A0S2Z4S4
swissprot - O60603
Ensembl - ENSG00000137462
  
Related genetic diseases (OMIM): 114500 - {Colorectal cancer, susceptibility to}, 114500
  246300 - {Leprosy, susceptibility to}, 246300
  607948 - {Mycobacterium tuberculosis, susceptibility to}, 607948
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr2ENSDARG00000037758Danio rerio
 TLR2BENSGALG00000034722Gallus gallus
 Tlr2ENSMUSG00000027995Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412329
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413029
TLR1 / Q15399 / toll like receptor 1ENSG0000017412528
TLR4 / O00206 / toll like receptor 4ENSG0000013686924
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191624
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666423
AC097637.1ENSG0000017336622
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973222
TLR5 / O60602 / toll like receptor 5ENSG0000018755420
TLR3 / O15455 / toll like receptor 3ENSG0000016434220
CD180 / Q99467 / CD180 moleculeENSG0000013406113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026906  Leucine rich repeat 5
 IPR027185  Toll-like receptor 2
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001775 cell activation IDA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002374 cytokine secretion involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IDA
 biological_processGO:0007612 learning ISS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014005 microglia development ISS
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032289 central nervous system myelin formation IEA
 biological_processGO:0032493 response to bacterial lipoprotein IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032613 interleukin-10 production IDA
 biological_processGO:0032640 tumor necrosis factor production ISS
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032728 positive regulation of interferon-beta production ISS
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production ISS
 biological_processGO:0032741 positive regulation of interleukin-18 production ISS
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway IDA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0038123 toll-like receptor TLR1:TLR2 signaling pathway TAS
 biological_processGO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
 biological_processGO:0042495 detection of triacyl bacterial lipopeptide IDA
 biological_processGO:0042496 detection of diacyl bacterial lipopeptide IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046209 nitric oxide metabolic process IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050765 negative regulation of phagocytosis ISS
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS
 biological_processGO:0051964 negative regulation of synapse assembly ISS
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071221 cellular response to bacterial lipopeptide TAS
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IDA
 biological_processGO:0071727 cellular response to triacyl bacterial lipopeptide IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IGI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0106003 amyloid-beta complex ISS
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008329 signaling pattern recognition receptor activity IDA
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0042497 triacyl lipopeptide binding IDA
 molecular_functionGO:0042834 peptidoglycan binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0071723 lipopeptide binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000135218 CD36 / P16671 / CD36 molecule  / complex / reaction
 ENSG00000174125 TLR1 / Q15399 / toll like receptor 1  / complex
 ENSG00000177243 P81534 / DEFB103B / defensin beta 103B  / reaction / complex
 ENSG00000185303 Q8IWL1 / SFTPA2 / surfactant protein A2  / reaction / complex
 ENSG00000133661 SFTPD / P35247 / surfactant protein D  / reaction / complex
 ENSG00000174130 TLR6 / Q9Y2C9 / toll like receptor 6  / complex
 ENSG00000122852 Q8IWL2 / SFTPA1 / surfactant protein A1  / complex / reaction






 

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