ENSMUSG00000027995


Mus musculus

Features
Gene ID: ENSMUSG00000027995
  
Biological name :Tlr2
  
Synonyms : Tlr2 / toll-like receptor 2
  
Possible biological names infered from orthology : O60603
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 83836272
Gene end: 83841767
  
Corresponding Affymetrix probe sets: 10498992 (MoGene1.0st)   1419132_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029623
NCBI entrez gene - 24088     See in Manteia.
MGI - MGI:1346060
RefSeq - NM_011905
RefSeq - XM_006501460
RefSeq Peptide - NP_036035
swissprot - G3X8Y8
Ensembl - ENSMUSG00000027995
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr2ENSDARG00000037758Danio rerio
 TLR2BENSGALG00000034722Gallus gallus
 TLR2ENSG00000137462Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149829
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482728
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377723
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900523
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532222
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458322
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052222
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916420
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163919
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027185  Toll-like receptor 2
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002374 cytokine secretion involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0032289 central nervous system myelin formation IEA
 biological_processGO:0032493 response to bacterial lipoprotein IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032613 interleukin-10 production IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0042495 detection of triacyl bacterial lipopeptide IEA
 biological_processGO:0042496 detection of diacyl bacterial lipopeptide IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046209 nitric oxide metabolic process IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IEA
 biological_processGO:0071727 cellular response to triacyl bacterial lipopeptide IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008329 signaling pattern recognition receptor activity IEA
 molecular_functionGO:0035325 Toll-like receptor binding IEA
 molecular_functionGO:0042497 triacyl lipopeptide binding IEA
 molecular_functionGO:0042834 peptidoglycan binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0071723 lipopeptide binding IEA


Pathways (from Reactome)
Pathway description
Beta defensins
Regulation of TLR by endogenous ligand
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0000181 abnormal circulating LDL cholesterol level "anomalous concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3gtm1Amk/Cd3gtm1Amk,Tg(Igh-Pim1)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6LiA * CBA

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Cd3gtm1Amk/Cd3gtm1Amk,Tg(Igh-Pim1)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6LiA * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0001652 colonic necrosis "pathologic death of cells within, or a portion of, the colon" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3gtm1Amk/Cd3gtm1Amk,Tg(Igh-Pim1)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6LiA * CBA

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: NOD.129P2-Tlr2tm1Aki

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0002319 hyperoxia "elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: Not Specified

Allelic Composition: Tlr2lngd/Tlr2lngd
Genetic Background: C57BL/6J-Tlr2lngd

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Fabp1-cre)1Mmt/?
Genetic Background: involves: 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: Not Specified

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr2lngd/Tlr2lngd
Genetic Background: C57BL/6J-Tlr2lngd

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0003916 decreased left ventricle weight "less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: NOD.129P2-Tlr2tm1Aki

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005116 abnormal circulating pituitary hormone level "aberration in the blood concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0006080 CNS ischemia "abnormal incidence of or response to loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008652 decreased interleukin-1 secretion "reduction in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr6tm1Aki/Tlr6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0009132 abnormal white fat cell size "anomaly in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: Not Specified

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0010266 decreased liver tumor incidence "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0011077 decreased macrophage nitric oxide production "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0011633 abnormal mitochondrial shape "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

 MP:0012320 abnormal body fat mass "aberrant fat-containing physical bulk or volume of the body" [MPD:Molly]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0020449 decreased microglial cell activation "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021789 Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*  / complex / reaction
 ENSMUSG00000046354 Defb14 / Q7TNV9 / Beta-defensin 14 / P81534* / DEFB103B* / DEFB103A* / defensin beta 103A* / defensin beta 103B*  / reaction / complex
 ENSMUSG00000044827 Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*  / complex
 ENSMUSG00000021795 Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*  / reaction / complex






 

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