Manteia - Molecule gene

ENSMUSG00000079164

Mus musculus

Features

Gene ID:	ENSMUSG00000079164

Biological name :	Tlr5

Synonyms :	Tlr5 / toll-like receptor 5

Possible biological names infered from orthology :	O60602

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H5
Gene start:	182954788
Gene end:	182976044

Corresponding Affymetrix probe sets:	10608697 (MoGene1.0st) 1450242_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000141458 Ensembl peptide - ENSMUSP00000106625 Ensembl peptide - ENSMUSP00000141318 NCBI entrez gene - 53791 See in Manteia. MGI - MGI:1858171 RefSeq - XM_017321704 RefSeq - XM_017321700 RefSeq - XM_017321701 RefSeq - XM_017321702 RefSeq - XM_017321703 RefSeq - NM_016928 RefSeq - XM_017321697 RefSeq - XM_017321698 RefSeq - XM_017321699 RefSeq Peptide - NP_058624 swissprot - E9QL10 swissprot - A0A0A6YVY4 swissprot - Q05AH3 Ensembl - ENSMUSG00000079164

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tlr5a	ENSDARG00000044415	Danio rerio
tlr5b	ENSDARG00000052322	Danio rerio
TLR5	ENSGALG00000009392	Gallus gallus
TLR5	ENSG00000187554	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tlr13 / Q6R5N8 / Toll-like receptor 13	ENSMUSG00000033777	22
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*	ENSMUSG00000045322	22
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*	ENSMUSG00000031639	22
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*	ENSMUSG00000044583	21
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*	ENSMUSG00000039005	20
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*	ENSMUSG00000040522	20
Tlr2 / toll-like receptor 2 / O60603*	ENSMUSG00000027995	18
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*	ENSMUSG00000044827	17
Tlr6 / toll-like receptor 6 / Q9Y2C9*	ENSMUSG00000051498	17
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*	ENSMUSG00000021624	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
IPR000483	Cysteine-rich flanking region, C-terminal
IPR001611	Leucine-rich repeat
IPR003591	Leucine-rich repeat, typical subtype
IPR027176	Toll-like receptor 5
IPR032675	Leucine-rich repeat domain superfamily
IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001819	positive regulation of cytokine production	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0008584	male gonad development	IEA
biological_process	GO:0034146	toll-like receptor 5 signaling pathway	IEA
biological_process	GO:0042742	defense response to bacterium	IEA
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IEA
biological_process	GO:0050707	regulation of cytokine secretion	IEA
biological_process	GO:0071222	cellular response to lipopolysaccharide	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0000231	hypertension	"sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0000493	rectal prolapse	"downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4^lps-del/Tlr4^lps-del,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tlr5^tm1Aki/Tlr5^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz} Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0001433	polyphagia	"eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz} Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4^lps-del/Tlr4^lps-del,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz} Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002376	abnormal dendritic cell physiology	"failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0002411	decreased susceptibility to bacterial infection	"reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Casp1^tm1Sesh/Casp1⁺,Casp4^del/Casp4⁺ Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * NOD
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz} Allelic Composition: Tlr4^tm1Aki/Tlr4^tm1Aki,Tlr5^tm1Flv/Tlr5^tm1Flv Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Jak2^tm1Kf/Jak2^tm1Kf Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac
MP:0002842	increased blood pressure	"increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Ccl2^tm1Rol/Ccl2^tm1Rol,Tg(Ccr2-GFP)8Pam/0 Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003304	large intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4^lps-del/Tlr4^lps-del,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL
MP:0004761	susceptibility to induced pancreatitis	"more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0004803	increased susceptibility to autoimmune diabetes	"greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz} Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0005658	susceptibility to diet-induced obesity	"more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0005666	abnormal adipose tissue physiology	"functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0005671	response to transplant	"the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0006143	increased diastolic blood pressure	"abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0006144	increased systolic blood pressure	"abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0008657	increased interleukin-1 beta secretion	"increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tlr5^tm1Aki/Tlr5^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0008670	decreased interleukin-12b secretion	"reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]	Show Allelic Composition: Casp1^tm1Sesh/Casp1⁺,Casp4^del/Casp4⁺ Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * NOD
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Casp1^tm1Sesh/Casp1⁺,Casp4^del/Casp4⁺ Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * NOD
MP:0008872	abnormal response to xenobiotics	"any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0008907	decreased total fat pad weight	"less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbrg1^{tm1a(KOMP)Wtsi}/Tbrg1⁺ Genetic Background: C57BL/6N-Tbrg1^{tm1a(KOMP)Wtsi}
MP:0008908	increased total fat pad weight	"greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0009288	increased epididymal fat pad weight		Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0010377	abnormal gut flora balance	"anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz} Allelic Composition: Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr,Tg(Itgax-cre,-EGFP)4097Ach/? Genetic Background: involves: C57BL/6J * C57BL/6NTac Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL Allelic Composition: Tlr5^tm1Aki/Tlr5^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0013298	increased susceptibility to colitis induced morbidity/mortality	" increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tlr5^tm1Aki/Tlr5^tm1Aki Genetic Background: involves: 129P2/OlaHsd
MP:0013956	decreased colon length	"reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]	Show Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4^lps-del/Tlr4^lps-del,Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL Allelic Composition: Tlr5^tm1Aki/Tlr5^tm1Aki Genetic Background: involves: 129P2/OlaHsd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr