ENSMUSG00000021624


Mus musculus

Features
Gene ID: ENSMUSG00000021624
  
Biological name :Cd180
  
Synonyms : Cd180 / CD180 antigen / Q62192
  
Possible biological names infered from orthology : CD180 molecule / Q99467
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D1
Gene start: 102693558
Gene end: 102739629
  
Corresponding Affymetrix probe sets: 10406928 (MoGene1.0st)   1421547_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127880
Ensembl peptide - ENSMUSP00000133015
Ensembl peptide - ENSMUSP00000131402
Ensembl peptide - ENSMUSP00000129096
Ensembl peptide - ENSMUSP00000022124
NCBI entrez gene - 17079     See in Manteia.
MGI - MGI:1194924
RefSeq - XM_017315401
RefSeq - NM_008533
RefSeq Peptide - NP_032559
swissprot - F2Z425
swissprot - E9Q009
swissprot - E9Q0I3
swissprot - Q62192
swissprot - E9PVS6
Ensembl - ENSMUSG00000021624
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd180ENSDARG00000093750Danio rerio
 CD180ENSGALG00000023411Gallus gallus
 CD180ENSG00000134061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052224
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532223
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458323
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163921
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900518
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916418
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377717
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799515
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482714
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002322 B cell proliferation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0005265 abnormal blood urea nitrogen level "aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb7tm1Cgn/Itgb7tm1Cgn,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * NZW

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021423 Ly86 / O88188 / Lymphocyte antigen 86 / O95711*  / complex






 

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