ENSMUSG00000021423


Mus musculus

Features
Gene ID: ENSMUSG00000021423
  
Biological name :Ly86
  
Synonyms : Ly86 / Lymphocyte antigen 86 / O88188
  
Possible biological names infered from orthology : O95711
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.3
Gene start: 37345208
Gene end: 37419036
  
Corresponding Affymetrix probe sets: 10404606 (MoGene1.0st)   1422903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021860
NCBI entrez gene - 17084     See in Manteia.
MGI - MGI:1321404
RefSeq - NM_010745
RefSeq Peptide - NP_034875
swissprot - O88188
Ensembl - ENSMUSG00000021423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ly86ENSDARG00000090649Danio rerio
 LY86ENSGALG00000012801Gallus gallus
 LY86ENSG00000112799Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003172  MD-2-related lipid-recognition domain
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021624 Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*  / complex






 

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