ENSMUSG00000044583


Mus musculus

Features
Gene ID: ENSMUSG00000044583
  
Biological name :Tlr7
  
Synonyms : P58681 / Tlr7 / toll-like receptor 7
  
Possible biological names infered from orthology : Q9NYK1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 167304929
Gene end: 167330558
  
Corresponding Affymetrix probe sets: 10607870 (MoGene1.0st)   1419848_x_at (Mouse Genome 430 2.0 Array)   1422010_at (Mouse Genome 430 2.0 Array)   1449640_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061853
Ensembl peptide - ENSMUSP00000107789
Ensembl peptide - ENSMUSP00000114305
Ensembl peptide - ENSMUSP00000120922
Ensembl peptide - ENSMUSP00000107787
NCBI entrez gene - 170743     See in Manteia.
MGI - MGI:2176882
RefSeq - XM_011247786
RefSeq - NM_001290755
RefSeq - NM_001290756
RefSeq - NM_001290757
RefSeq - NM_001290758
RefSeq - NM_133211
RefSeq - XM_006528713
RefSeq - XM_011247785
RefSeq Peptide - NP_001277684
RefSeq Peptide - NP_001277686
RefSeq Peptide - NP_001277687
RefSeq Peptide - NP_573474
RefSeq Peptide - NP_001277685
swissprot - P58681
swissprot - A2AHJ2
swissprot - Q548J0
swissprot - A2AHJ1
Ensembl - ENSMUSG00000044583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr7ENSDARG00000068812Danio rerio
 TLR7ENSGALG00000016590Gallus gallus
 TLR7ENSG00000196664Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052242
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532235
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163922
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377722
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916418
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900518
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799516
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162415
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149815
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026880  Toll-like receptor 7
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation ISO
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0034154 toll-like receptor 7 signaling pathway IEA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process IMP
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process ISO
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process ISS
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0003725 double-stranded RNA binding ISS
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0035197 siRNA binding IMP


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0000701 abnormal lymph node size "deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Tiraptm1Aki/Tiraptm1Aki
Genetic Background: B6.129P2-Tiraptm1Aki

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx2tm1Hmd/Pitx2tm1Hmd
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

Allelic Composition: Tlr7rsq1/Y
Genetic Background: C57BL/6J-Tlr7rsq1

Allelic Composition: Tlr7rsq2/Y
Genetic Background: C57BL/6J-Tlr7rsq2

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002870 decreased insulin autoantibody level "reduced level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

Allelic Composition: Tlr7tm1Flv/Y
Genetic Background: B6.129S1-Tlr7tm1Flv

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Pitx2tm1Hmd/Pitx2tm1Hmd
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

Allelic Composition: Tlr7rsq1/Y
Genetic Background: C57BL/6J-Tlr7rsq1

Allelic Composition: Tlr7rsq2/Y
Genetic Background: C57BL/6J-Tlr7rsq2

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Tiraptm1Aki/Tiraptm1Aki
Genetic Background: B6.129P2-Tiraptm1Aki

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Tlr7tm1Flv/Y,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr7tm1Flv/Y
Genetic Background: B6.129S1-Tlr7tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000036908 Unc93b1 / unc-93 homolog B1 (C. elegans) / Q9H1C4* / unc-93 homolog B1, TLR signaling regulator*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000020048 P08113 / Hsp90b1 / heat shock protein 90, beta (Grp94), member 1 / P14625* / heat shock protein 90 beta family member 1*  / complex / reaction
 ENSMUSG00000023973 3 / Cnpy3 / Q9DAU1 / Q9BT09* / canopy FGF signaling regulator 3*  / reaction / complex
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / reaction / complex
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / complex / reaction






 

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